Test ID: ESTF
Estrogens, Estrone (E1) and Estradiol (E2), Fractionated, Serum
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
This test allows the simultaneous high-sensitivity determination of serum estrone and estradiol levels. It is useful in situations requiring either higher sensitivity estradiol measurement, or estrone measurement, or both. This includes the following:
-As part of the diagnosis and work-up of precocious and delayed puberty in females, and, to a lesser degree, males
-As part of the diagnosis and work-up of suspected disorders of sex steroid metabolism, eg, aromatase deficiency and 17 alpha-hydroxylase deficiency
-As an adjunct to clinical assessment, imaging studies, and bone mineral density measurement in the fracture risk assessment of postmenopausal women, and, to a lesser degree, older men
-Monitoring low-dose female hormone replacement therapy in postmenopausal women
-Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy)
Useful in all applications that require moderately sensitive measurement of estradiol including:
-Evaluation of hypogonadism and oligo-amenorrhea in females
-Assessing ovarian status, including follicle development, for assisted reproduction protocols (eg, in vitro fertilization)
In conjunction with luteinizing hormone measurements, monitoring of estrogen replacement therapy in hypogonadal premenopausal women
Evaluation of feminization, including gynecomastia, in males
Diagnosis of estrogen-producing neoplasms in males, and, to a lesser degree, females
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| E1 | Estrone, S | Yes | Yes |
| EEST | Estradiol, S | Yes | Yes |
Method Name A short description of the method used to perform the test
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Estradiol
Estrogens, total
Estrone
Total Estrogens
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