Test ID: TTRX
Amyloidosis, Transthyretin-Associated Familial, Reflex, Blood
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
Useful For Suggests clinical disorders or settings where the test may be helpful
Diagnosis of adult individuals suspected of having transthyretin (TTR)-associated familial amyloidosis
Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request
Mass spectrometry to evaluate TTR protein structure is performed first. In all cases demonstrating a structural change, the TTR gene will be further analyzed by DNA sequence analysis. If no alterations are detected, subsequent gene analysis will not be performed unless a request for AMYL/83667 Amyloidosis, Transthyretin-Associated Familial, DNA Sequence, Blood is submitted by the ordering physician or client.
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Secondary ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|---|
| AMYL | 83667 | Familial Amyloidosis, DNA Sequence | Yes | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
If familial amyloidosis by liquid chromatography-mass spectrometry is abnormal, AMYL/83667 Amyloidosis, Transthyretin-Associated Familial, DNA Sequence, Blood will be ordered and charged separately.
See Amyloidosis (Familial) Test Algorithm in Special Instructions.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
TTRX/83674: Liquid Chromatography-Mass Spectrometry (LC-MS)
AMYL/83667: Polymerase Chain Reaction (PCR) Amplification/DNA Sequencing
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)
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