Unit Code 83380:
Paraneoplastic Autoantibody Evaluation, Serum
Useful For
Serological evaluation of patients who present with a subacute
neurological disorder of undetermined etiology,
especially those with known risk factors for cancer.
Directing a focused search for cancer
Investigating neurological symptoms that appear in the course of,
or after, cancer therapy, and are not explainable by metastasis
Differentiating autoimmune neuropathies from neurotoxic effects
of chemotherapy
Monitoring the immune response of seropositive patients in the
course of cancer therapy
Detecting early evidence of cancer recurrence in previously
seropositive patients
Profile Information
| Unit Code | Reporting Name | Available Separately | Always Performed |
| 83381 | Anti-Neuronal Nuclear Ab, Type 1 | No | Yes |
| 83382 | Anti-Neuronal Nuclear Ab, Type 2 | No | Yes |
| 83137 | Anti-Neuronal Nuclear Ab, Type 3 | No | Yes |
| 89080 | Anti-Glial Nuclear Ab, Type 1 | No | Yes |
| 83383 | Purkinje Cell Cytoplasmic Ab Type 1 | No | Yes |
| 83138 | Purkinje Cell Cytoplasmic Ab Type 2 | No | Yes |
| 83076 | Purkinje Cell Cytoplasmc Ab Type Tr | No | Yes |
| 83386 | Amphiphysin Ab, S | No | Yes |
| 83077 | CRMP-5-IgG, S | No | Yes |
| 8746 | Striational (Striated Muscle) Ab, S | Yes | Yes |
| 81185 | P/Q-Type Calcium Channel Ab | No | Yes |
| 81184 | N-Type Calcium Channel Ab | No | Yes |
| 8338 | ACh Receptor (Muscle) Binding Ab | Yes | Yes |
| 84321 | AChR Ganglionic Neuronal Ab, S | No | Yes |
| 89165 | Neuronal (V-G) K Channel Ab, S | No | Yes |
Reflex Tests
| Unit Code | Reporting Name | Available Separately | Always Performed |
| 83107 | CRMP-5-IgG Western Blot, S | No | No |
| 81596 | GAD65 Ab Assay, S | Yes | No |
| 83378 | ACh Receptor (Muscle) Modulating Ab | No | No |
| 83379 | ACh Receptor (Muscle) Blocking Ab | No | No |
| 83108 | Paraneoplastic Autoantibody WBlot,S | No | No |
Testing Algorithm
If IFA (83381, 83382, 83137, 83383, 83138, 83076, 83386, 83077)
patterns are indeterminate, paraneoplastic autoantibody
Western blot is performed at an additional charge.
If client requests or if IFA patterns suggest CRMP-5-IgG,
CRMP-5-IgG Western blot is performed at an additional charge.
If P/Q-Type or N-Type calcium channel is >0.02, CRMP-5-IgG
Western blot is performed at an additional charge.
If IFA patterns suggests GAD65 antibody, GAD65 antibody
RIA is performed at an additional charge.
If ACh receptor binding antibody is >0.02 or if striational
antibodies are > or = 1:60, ACh receptor modulating antibodies
and CRMP-5-IgG Western blot are performed at an additional
charge. If ACh receptor modulating antibodies are > or =40% loss,
RIA for ACh receptor blocking antibodies performed at an additional
charge. If AChR ganglionic neuronal antibodies are > or =0.03,
CRMP-5-IgG Western blot is performed at an additional charge.
Special Instructions and Forms
Method Name
83381, 83382, 83137, 83383, 83138, 83076, 83386, 83077, 89080:
Indirect Immunofluorescence assay (IFA)
8746: Enzyme Immunoassay (EIA)
81185, 81184, 81596, 8338, 83378, 83379, 84321, 89165:
Radioimmunoassay (RIA)
83108, 83107: Western Blot
General Information:
CRMP-5-IgG Western blot is also performed by specific request
for more sensitive detection of CRMP-5-IgG. Testing should be
requested in cases of subacute basal ganglionic disorders (chorea,
Parkinsonism), cranial neuropathies (especially loss of vision,
taste, or smell) and myelopathies.
See "Paraneoplastic Evaluation Algorithm" in Special Instructions.
Reporting Name
Paraneoplastic Autoantibody Eval, S
Ordering Mnemonic
PAEVAL
Aliases
Acetylcholine Receptor (Muscle AChR) Antibodies
AChR (Acetylcholine Receptor)
AGNA
Amphiphysin Antibody, Serum
ANNA (Antineuronal Nuclear Antibody)
Anti-CV2
Anti-Enteric Neuronal Antibody
Anti-GAD65 (Anti-Glutamic Acid Decarboxylase)
Anti-Glial Nuclear Antibody
Anti-Hu
Anti-Purkinje Cell Cytoplasmic Antibodies
Anti-Ri
Anti-Skeletal Muscle Antibodies
Anti-Yo
Antineuronal
APCA (Anti-Purkinje Cell Antibodies)
Calcium Channel Blockers
Cantoxin (Receptor Antibodies
Cerebellar Antibodies
Chorea
Collapsin Response-Mediator Protein-5 Antibody (CRMP-5), Serum
Cramp-fasciculation
CRMP-5, IgG
Dorsal Root Ganglion Antibody
GAD65 (Glutamic Acid Decarboxylase)
Glutamate Decarboxylase Antibodies (GAD65)
Hu Antibody
ICab (Islet Cell Cytoplasmic Antibody)
Isaacs disease
Islet Cell Cytoplasmic Antibody (ICAb)
Motor End-Plate Antibody
Motor Nerve Terminal Antibodies
Muscle (Skeletal) Antibodies
Muscle Culture Antibodies
Myoid Antibody
N-Type Calcium Channel Antibody
Neuromuscular hyperexcitability
Neuromyotonia
Neuronal ganglionic acetylcholine receptor antibody
Neuronal Nuclear Antibody
Neuronal Nuclear Antibody Panel
Neuronal Potassium Channel Ab
Neuronal-Anti
Ovarian Cancer-Related Antibodies
P/Q Type Calcium Channel Antibody
Paraneoplastic Antibodies
Paraneoplastic Autoantibody Evaluation
Paraneoplastic Neurological Autoimmunity
PCA-1 (Purkinje Cell Cytoplasmic Antibodies)
PCA-2 (Purkinje Cell Cytoplasmic Antibodies)
PCA-Tr (Purkinje Cell Cytoplasmic Antibodies)
PCAb (Purkinje Cell Cytoplasmic Antibodies)
Potassium Channel Ab
Potassium Channel Antibodies (specify)
Purkinje Cell Cytoplasmic Antibodies, Type 1
Purkinje Cell Cytoplasmic Antibodies, Type 2
Purkinje Cell Cytoplasmic Antibodies, Type Tr
Ri, Anti
Stiff-man Syndrome
Striational (Striated Muscle) Antibodies
VGCC (Voltage-Gated Calcium Channel) Antibodies
VGKC
VGPC
Voltage-Gated Potassium Channel Ab
Yo-Anti
External link
PDF document
Excel document
Word document