Test ID: MGEA
Myasthenia Gravis (MG) Evaluation, Adult
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Initial evaluation of patients aged 20 or older with symptoms and signs of acquired myasthenia gravis (MG)
Bone marrow transplant recipients with suspected graft-versus-host disease, particularly if weakness has appeared
Confirming that a recently acquired neurological disorder has an autoimmune basis (eg, MG)
Providing a quantitative baseline for future comparisons in monitoring a patient's clinical course and the response to immunomodulatory treatment
Raising likelihood of neoplasia
If muscle AChR modulating antibody value is (or exceeds) 90% acetylcholine receptor (AChR) loss and striational antibody is detected, thymoma is likely. Reflexive testing will include CRMP-5-lgG Western blot, ganglionic AChR antibody, GAD65 antibody, and VGKC antibody (which are frequent with thymoma).
Note: Single antibody tests may be requested in follow-up of patients with positive results documented in this laboratory.
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ARBI | ACh Receptor (Muscle) Binding Ab | Yes | Yes |
| ARMO | ACh Receptor (Muscle) Modulating Ab | No | Yes |
| STR | Striational (Striated Muscle) Ab, S | Yes | Yes |
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| GD65S | GAD65 Ab Assay, S | Yes | No |
| CRMWS | CRMP-5-IgG Western Blot, S | No | No |
| GANG | AChR Ganglionic Neuronal Ab, S | No | No |
| VGKC | Neuronal (V-G) K+ Channel Ab, S | No | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
If AChR modulating antibodies are > or =90% and striational antibodies are > or =1:60, AChR ganglionic neuronal autoantibody, glutamic acid decarboxylase autoantibody, neuronal voltage-gated potassium channel (VGKC) autoantibody, and CRMP-5-IgG Western blot will be performed at an additional charge.
See Myasthenia Gravis: Adult Diagnostic Algorithm in Special Instructions.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
ARBI/8338, ARMO/83378, GANG/84321, GD65S/81596, VGKC/89165: Radioimmunoassay (RIA)
STR/8746: Enzyme Immunoassay (EIA)
CRMWS/83107: Western Blot
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
AChR (Acetylcholine Receptor)
Anti-Skeletal Muscle Antibodies
GAD65 (Glutamic Acid Decarboxylase)
Muscle End-Plate Antibodies
Myasthenia Gravis Antibodies
Myoid Antibody
Neuronal Potassium Channel Ab
Striational (Striated Muscle) Antibodies
VGKC
VGPC
Voltage-Gated Potassium Channel Ab
Potassium Channel Antibodies (specify)
Glutamate Decarboxylase Antibodies (GAD65)
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