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Investigating possible disorders of mitochondrial metabolism, when used in conjunction with cerebrospinal fluid lactate collected at the same time to determine the lactate-to-pyruvate ratio
Evaluating patients with neurologic dysfunction and normal blood lactate-to-pyruvate ratios
The CSF lactate:pyruvate (L:P) ratio is considered a helpful (not diagnostic) tool in the evaluation of patients with possible disorders of mitochondrial metabolism, especially in patients with neurologic dysfunction and normal blood L:P ratios. Pyruvic acid levels alone have little clinical utility.