THRMP - Overview: Thrombophilia Profile

Test Catalog

Test ID: THRMP    
Thrombophilia Profile

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluating patients with thrombosis or hypercoagulability states


Detecting a lupus-like anticoagulant; dysfibrinogenemia; disseminated intravascular coagulation/intravascular coagulation and fibrinolysis


Detecting a deficiency of antithrombin, protein C, or protein S


Detecting activated protein C resistance (and the factor V R506Q [Leiden] mutation if indicated)


Detecting the prothrombin G20210A mutation

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
PTCProthrombin Time (PT), PYes, (order PTTP)Yes
APTTBActivated Partial Thrombopl Time, PYes, (order APTTP)Yes
DRVTDilute Russells Viper Venom Time, PYes, (Order DRVTI)Yes
TTThrombin Time (Bovine), PYesYes
FIBCFibrinogen, PYes, (order FIBTP)Yes
DIRMD-Dimer, PYes, (order DDITTYes
SFMSoluble Fibrin MonomerNoYes
ATTFAntithrombin Activity, PYesYes
CFXProtein C Activity, PYesYes
PSFProtein S Ag, Free, PYes, (order PSTF)Yes
PTNTProthrombin G20210A Mutation, BYesYes
APCRVActivated Protein Resistance V, PYesYes
CCCSpecial Coagulation InterpretationNoYes

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
IBETHBethesda UnitsNoNo
F8ISCoag Factor VIII Assay Inhib Scrn,PNoNo
ATTIAntithrombin Antigen, PYesNo
FACTVCoag Factor V Assay, PYesNo
F_7Coag Factor VII Assay, PYesNo
F_9Coag Factor IX Assay, PYesNo
F_10Coag Factor X Assay, PYesNo
F_11Coag Factor XI Assay, PYesNo
F_12Coag Factor XII Assay, PYesNo
F8ACoag Factor VIII Activity Assay, PYesNo
RPTLReptilase Time, PYesNo
PSGNPlasminogen Activity, PYesNo
F_2Coag Factor II Assay, PYesNo
PCAGProtein C Ag, PYesNo
S_FXProtein S Activity, PYesNo
F5DNAFactor V Leiden (R506Q) Mutation, BYesNo
PNPPlatelet Neutralization ProcedureNoNo
PTMXPT Mix 1:1NoNo
PSTProtein S Ag, Total, PNoNo
STLAStaclot LA, PNoNo
DRVTCDRVVT ConfirmationNoNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

Initial testing includes: prothrombin time (PT); activated partial thromboplastin time (APTT); dilute Russells viper venom time (DRVVT); thrombin time (bovine); fibrinogen; D-dimer; soluble fibrin monomer; antithrombin activity; protein C activity; protein S antigen, free; prothrombin G20210A mutation; activated protein resistance V; and, if appropriate, special coagulation interpretation.

If PT is > or =14 seconds, PT mix will be performed.

If APTT is >36 seconds, APTT mix will be performed.

If APTT mix is >36 seconds with no evidence of heparin in samples, platelet neutralization procedure will be performed.

If DRVVT ratio is > or =1.2, DRVVT mix and DRVVT confirmation will be performed.

If thrombin time is >23 seconds, reptilase time will be performed.

If protein S antigen, free is <65% for males and females > or =50 years of age and <50% for females <50 years of age, protein S antigen, total will be performed.

If protein C activity is <70% with no evidence for an acquired decrease in protein C activity, protein C antigen may be performed.

If antithrombin activity is <80% with no evidence of an acquired decrease in antithrombin activity, antithrombin antigen will be performed.

If activated protein C resistance (APC) ratio is <2.3 or baseline APC APTT is prolonged, factor V leiden (R506Q) mutation analysis will be performed.

If appropriate, protein S activity, plasminogen, coagulation factor assays, or Staclot LA will be performed at an additional charge to clarify significant abnormalities in the screening clotting times.

If factor VIII result is <55%, the factor VIII inhibitor screen may be performed along with the Bethesda titering assay, if inhibitor screen is positive.


See Thrombophilia Profile algorithm in Special Instructions.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test


FIBC: Clauss Methodology

DIRM, PSF, PST: Automated Latex Immunoassay (LIA)

SFM: Immunoturbidimetric

ATTF, CFX: Chromogenic Assay

PTNT: Direct Mutation Analysis

PNP: Activated Partial Thromboplastin Time (APTT) Mixing Test

IBETH, F8IS: Clot-Based Assay

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Thrombophilia Prof

Aliases Lists additional common names for a test, as an aid in searching

Thrombophilia Profile