Test ID: THRMP
Thrombophilia Profile
NY State Approved 
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Evaluating patients with thrombosis or hypercoagulability states
Detecting a lupus-like anticoagulant; dysfibrinogenemia; disseminated intravascular coagulation/intravascular coagulation and fibrinolysis
Detecting a deficiency of antithrombin, protein C, or protein S
Detecting activated protein C resistance (and the factor V R506Q [Leiden] mutation if indicated)
Detecting the prothrombin G20210A mutation
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| PTC | Prothrombin Time (PT), P | Yes, (order PT) | Yes |
| APTTB | Activated Partial Thrombopl Time, P | Yes, (order APT) | Yes |
| DRVT | Dilute Russells Viper Venom Time, P | No | Yes |
| TT | Thrombin Time (Bovine), P | Yes | Yes |
| FIBC | Fibrinogen, P | Yes, (order FIB) | Yes |
| DIRM | D-Dimer, P | Yes, (order DDI) | Yes |
| SFM | Soluble Fibrin Monomer | No | Yes |
| ATTF | Antithrombin Activity, P | Yes | Yes |
| CFX | Protein C Activity, P | Yes | Yes |
| PSF | Protein S Ag, Free, P | Yes, (order PSTF) | Yes |
| PTNT | Prothrombin G20210A Mutation, B | Yes | Yes |
| APCRV | Activated Protein Resistance V, P | Yes | Yes |
| CCC | Special Coagulation Interpretation | No | Yes |
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IBETH | Bethesda Units | No | No |
| F8IS | Coag Factor VIII Assay Inhib Scrn,P | No | No |
| ATTI | Antithrombin Antigen, P | Yes | No |
| FACTV | Coag Factor V Assay, P | Yes | No |
| F_7 | Coag Factor VII Assay, P | Yes | No |
| F_9 | Coag Factor IX Assay, P | Yes | No |
| F_10 | Coag Factor X Assay, P | Yes | No |
| F_11 | Coag Factor XI Assay, P | Yes | No |
| F_12 | Coag Factor XII Assay, P | Yes | No |
| F8A | Coag Factor VIII Activity Assay, P | Yes | No |
| RPTL | Reptilase Time, P | Yes | No |
| PSGN | Plasminogen Activity, P | Yes | No |
| F_2 | Coag Factor II Assay, P | Yes | No |
| PCAG | Protein C Ag, P | Yes | No |
| S_FX | Protein S Activity, P | Yes | No |
| F5DNA | Factor V Leiden (R506Q) Mutation, B | Yes | No |
| PNP | Platelet Neutralization Procedure | No | No |
| PTMX | PT Mix 1:1 | No | No |
| APTTM | APTT Mix 1:1 | No | No |
| PST | Protein S Ag, Total, P | No | No |
| STLA | Staclot LA, P | No | No |
| DRVTM | DRVVT Mix | No | No |
| DRVTC | DRVVT Confirmation | No | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
Initial testing includes: prothrombin time (PT); activated partial thromboplastin time (APTT); dilute Russells viper venom time (DRVVT); thrombin time (bovine); fibrinogen; D-dimer; soluble fibrin monomer; antithrombin activity; protein C activity; protein S antigen, free; prothrombin G20210A mutation; activated protein resistance V; and, if appropriate, special coagulation interpretation.
If PT is > or =14 seconds, PT mix will be performed.
If APTT is >36 seconds, APTT mix will be performed.
If APTT mix is >36 seconds with no evidence of heparin in samples, platelet neutralization procedure will be performed.
If DRVVT ratio is > or =1.2, DRVVT mix will be performed.
If DRVVT mix ratio is > or =1.2, DRVVT confirmation will be performed.
If thrombin time is >23 seconds, reptilase time will be performed.
If protein S antigen, free is <65% for males and females > or =50 years of age and <50% for females <50 years of age, protein S antigen, total will be performed.
If protein C activity is <70% with no evidence for an acquired decrease in protein C activity, protein C antigen may be performed.
If antithrombin activity is <80% with no evidence of an acquired decrease in antithrombin activity, antithrombin antigen will be performed.
If activated protein C resistance (APC) ratio is <2.3 or baseline APC APTT is prolonged, factor V leiden (R506Q) mutation analysis will be performed.
If appropriate, protein S activity, plasminogen, coagulation factor assays, or Staclot LA will be performed at an additional charge to clarify significant abnormalities in the screening clotting times.
If factor VIII result is <55%, the factor VIII inhibitor screen may be performed along with the Bethesda titering assay, if inhibitor screen is positive.
See Thrombophilia Profile algorithm in Special Instructions.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
PTC/6599, PTMX/9053, APTTB/6548, APTTM/9118, DRVT/80340, TT/9059, RPTL/9078, STLA/82756, APCRV/81967, DRVTM/32467, DRVTC/32468: Clot-Based Assay
FIBC/80343: Clauss Methodology
DIRM/6625, PSF/80338, PST/80994, ATTI/9031: Automated Latex Immunoassay (LIA)
SFM/6600: Immunoturbidimetric
ATTF/9030, CFX/9339: Chromogenic Assay
PSGN/9079: Amidolysis of Chromogenic Substrate
S_FX/80775: Clot-Based End point Thromboplastin (APTT) Test System
F5DNA/81419, PTNT/81742: Direct Mutation Analysis
PNP/8866: Activated Partial Thromboplastin Time (APTT) Mixing Test
F_2/9121, FACTV/9054, F_7/9055, F_10/9066: Prothrombin Clot-Based Assay
F8A/9070, F_9/9065, F_11/9067, F_12/9069: Activated Partial Thromboplastin Time Clot-Based Assay
PCAG/9127: Enzyme Linked Immunosorbent Assay (ELISA)
IBETH/7288, F8IS/7289: Clot-Based Assay
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Thrombophilia Profile
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