Test ID: LUPPR
Lupus Anticoagulant Profile
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.
Useful For Suggests clinical disorders or settings where the test may be helpful
Confirming or excluding presence of lupus anticoagulant (LAC) distinguishing LAC from specific coagulation factor inhibitors and nonspecific inhibitors
Investigation of a prolonged activated thromboplastin time, especially when combined with other coagulation studies
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| PTC | Prothrombin Time (PT), P | Yes, (order PT) | Yes |
| APTTB | Activated Partial Thrombopl Time, P | Yes, (order APT) | Yes |
| DRVT | Dilute Russells Viper Venom Time, P | No | Yes |
| CCC1 | Interpretation | No | Yes |
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| DIRM | D-Dimer, P | Yes, (order #9290) | No |
| IBETH | Bethesda Units | No | No |
| F8IS | Coag Factor VIII Assay Inhib Scrn,P | No | No |
| FACTV | Coag Factor V Assay, P | Yes | No |
| F_7 | Coag Factor VII Assay, P | Yes | No |
| TT | Thrombin Time (Bovine), P | Yes | No |
| F_9 | Coag Factor IX Assay, P | Yes | No |
| F_10 | Coag Factor X Assay, P | Yes | No |
| F_11 | Coag Factor XI Assay, P | Yes | No |
| F_12 | Coag Factor XII Assay, P | Yes | No |
| F8A | Coag Factor VIII Activity Assay, P | Yes | No |
| RPTL | Reptilase Time, P | Yes | No |
| F_2 | Coag Factor II Assay, P | Yes | No |
| FIBC | Fibrinogen, P | Yes, (order #8484) | No |
| SFM | Soluble Fibrin Monomer | No | No |
| PNP | Platelet Neutralization Procedure | No | No |
| PTMX | PT Mix 1:1 | No | No |
| APTTM | APTT Mix 1:1 | No | No |
| DRVTM | DRVVT Mix | No | No |
| DRVTC | DRVVT Confirmation | No | No |
| CCC2 | Special Coagulation Interpretation | No | No |
| STLA | Staclot LA, P | No | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
Initial testing includes: prothrombin time (PT), activated partial thromboplastin time (APTT), and dilute Russell's viper venom time (DRVVT).
If the PT, APTT, and DRVVT are normal, a computer-generated interpretive comment indicating no evidence of a lupus anticoagulant will be provided.
If PT is > or =14 seconds, PT mix will be performed.
If APTT is >36 seconds, APTT mix will be performed.
If APTT mix is >36 seconds with no evidence of heparin in sample, platelet neutralization procedure (PNP) will be performed.
If DRVVT ratio is > or =1.2, DRVVT mix will be performed.
If DRVVT mix ratio is > or =1.2, DRVVT confirm will be performed.
If PT, APTT, or DRVVT are prolonged, thrombin time (TT) will be performed.
If TT is >23 seconds, reptilase will be performed.
If appropriate, coagulation factor assays, fibrinogen, D-dimer, Staclot LA, and soluble fibrin monomer will be performed to clarify a significant abnormality in the screening clotting times.
If factor VIII result is <55%, the factor VIII inhibitor screen may be performed along with the Bethesda titering assay, if indicated.
If any test results are abnormal, all results will be reviewed by a coagulation consultant and a Special Coagulation Consultant Interpretation will be provided.
See Lupus Anticoagulant Profile Testing Algorithm in Special Instructions.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
Method Name A short description of the method used to perform the test
PTC/6599, PTMX/9053, APTTB/6548, DRVT/80340, TT/9059, RPTL/9078, DRVTM/32467, DRVTC/32468, APTTM/9118, STLA/82756: Clot-Based Assay
DIRM/6625: Automated Latex Immunoassay (LIA)
PNP/8866: Activated Partial Thromboplastin Time (APTT) Mixing Test
F_2/9121, FACTV/9054, F_7/9055, F_10/9066, IBETH/7288, F8IS/7289: Prothrombin Clot-Based Assay
F8A/9070, F_9/9065, F_11/9067, F_12/9069: Activated Partial Thromboplastin Clot-Based Assay
FIBC/80343: Clauss Methodology
SFM/6600: Immunoturbidimetric
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
Coag
Dilute Russell Viper Venom Time (DRVVT)
DRVVT (Dilute Russell Viper Venom Time)
Phospholipid Antibodies
Platelet Neutralization Procedure (PNP Coag Consult)
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