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Test ID: A1ATR    
Alpha-1-Antitrypsin Deficiency Profile

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Useful For Suggests clinical disorders or settings where the test may be helpful

This is Mayo's preferred approach for diagnosing alpha-1-antitrypsin deficiency (alpha-1-antitrypsin quantitation and genotype).


Determining the specific allelic variant (genotyping) for prognosis and genetic counseling

Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request

Profile includes serum alpha-1-antitrypsin levels and molecular analysis (S and Z alleles). If the genotyping and quantitative serum level are discordant, A1ATP / Alpha-1-Antitrypsin (A1A) Phenotyping, Serum will be added and performed at an additional charge.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
A1ATAlpha-1-Antitrypsin Genotyping, BNoYes
AATQAlpha-1-Antitrypsin, SYes, (order AAT)Yes

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
A1ATPA1AT Phenotype, SYes, (order A1APP)No

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If the genotyping and quantitative serum level are discordant, then alpha-1-antitrypsin phenotyping, will be added and performed at an additional charge.


See Alpha-1-Antitrypsin-A Comprehensive Testing Algorithm in Special Instructions.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

A1AT: Polymerase Chain Reaction (PCR)

(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

AATQ: Nephelometry

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

A1AT Deficiency Profile

Aliases Lists additional common names for a test, as an aid in searching

AAT (Alpha-1-Antitrypsin)
Alpha 1 Antitrypsin
Alpha one Antitrypsin
Alpha1-Proteinase Inhibitor (Prolastin)
Pi Typing
Prolastin (Alpha1-Proteinase Inhibitor)
Protease Inhibitor Allo Typing