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Test ID: FHER2    
HER2 Amplification Associated with Breast Cancer, FISH, Tissue

Available on the App Store

Secondary ID A test code used for billing and in test definitions created prior to November 2011

81954

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Useful For Suggests clinical disorders or settings where the test may be helpful

A prognostic indicator for patients with both node-positive or node-negative primary and metastatic breast cancer

 

Guiding therapy, as patients with HER2 amplification may be candidates for therapies that target the human epidermal growth factor receptor 2 (HER2) protein (eg, trastuzumab [Herceptin], pertuzumab, lapatinib)

 

Confirming the presence of HER2 amplification in cases with 2+ (low level) or 3+ (high level) HER2 overexpression by immunohistochemistry

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

This test does not include a pathology consult. If a pathology consult is requested, 70012 / Pathology Consultation should be ordered and the appropriate FISH test will be ordered and performed at an additional charge.

Reflex testing will be performed using the HER2/D17S122 probe when the HER2:D17Z1 result is equivocal as defined by 2013 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines.

Method Name A short description of the method used to perform the test

Fluorescence In Situ Hybridization (FISH)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

HER2 Amp, Breast Cancer, FISH

Aliases Lists additional common names for a test, as an aid in searching

Breast Carcinoma
c-erb-b2 Amplification Test (FISH)