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Test ID: FBALL    
B-Cell Acute Lymphoblastic Leukemia (ALL), FISH

Available on the App Store

Secondary ID A test code used for billing and in test definitions created prior to November 2011

81616

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting a neoplastic clone associated with the common chromosome anomalies seen in patients with B-cell acute lymphoblastic leukemia (B-ALL)

 

Identifying and tracking known chromosome abnormalities in patients with B-ALL and tracking response to therapy

 

As an adjunct to conventional chromosome studies in patients with B-ALL

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
ADD1FOne Additional FISH ProbeNoNo
ADD2FTwo Additional FISH ProbesNoNo
ADD4FFour Additional FISH ProbesNoNo
ADD3FThree Additional FISH ProbesNoNo
ADD5FFive Additional FISH ProbesNoNo
ADD6FSix Additional FISH ProbesNoNo
ADD7FSeven Additional FISH ProbesNoNo
ADD8FEight Additional FISH ProbesNoNo
ADD9FNine Additional FISH ProbesNoNo
ADD10Ten Additional FISH ProbesNoNo
ADD11Eleven Additional FISH ProbesNoNo
ADD12Twelve Additional FISH ProbesNoNo
14FPFourteen Additional FISH ProbesNoNo
13FPThirteen Additional FISH ProbesNoNo
15FPFifteen Additional FISH ProbesNoNo
16FPSixteen Additional FISH ProbesNoNo
17FPSeventeen Additional FISH ProbesNoNo
18FPEighteen Additional FISH ProbesNoNo
19FPNineteen Additional FISH ProbesNoNo
20FPTwenty Additional FISH ProbesNoNo
21FPTwenty One Additional FISH ProbesNoNo
22FPTwenty Two Additional FISH ProbesNoNo
23FPTwenty Three Additional FISH ProbesNoNo
24FPTwenty Four Additional FISH ProbesNoNo
25FPTwenty Five Additional FISH ProbesNoNo
26FPTwenty Six Additional FISH ProbesNoNo
27FPTwenty Seven Additional FISH ProbesNoNo
28FPTwenty Eight Additional FISH ProbesNoNo
29FPTwenty Nine Additional FISH ProbesNoNo
30FPThirty Additional FISH ProbesNoNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

We recommend the following testing algorithm for patients with B-Cell Acute Lymphoblastic Leukemia (B-ALL):

-At diagnosis, conventional cytogenetic studies (BM / Chromosome Analysis, Hematologic Disorders, Bone Marrow) and a complete B-ALL FISH panel should be performed.

-At follow-up, conventional cytogenetic studies (BM / Chromosome Analysis, Hematologic Disorders, Bone Marrow) and targeted B-ALL FISH probes based on the abnormalities identified in the diagnostic study can be evaluated.

-If the patient clinically relapses, a conventional chromosome study is useful to identify cytogenetic changes in the neoplastic clone or the possible emergence of a new therapy-related myeloid clone.

 

The number of probes ordered will determine the price of the testing. When this test is ordered, a charge for 2 FISH probes and interpretation is included. If additional probes or the entire panel are ordered, additional probe charges will be added.

 

Panel includes testing for the following abnormalities via the probes listed:

t(9;22), BCR/ABL1

t(12;21), ETV6/RUNX1

t(1;19), PBX1/TCF3

+4, +10, +17, Cen4/Cen10/Cen17

t(11q23;var), MLL

del(9p), CDKN2A/Cen9

t(14;var), IGH

17p-, TP53/Cen17

 

When an MLL rearrangement is identified, reflex testing is performed to identify the translocation partner. Probes include identification of t(4;11) AFF1/MLL, t(9;11) MLLT3/MLL, t(11;19)(q23;p13.1) MLL/ELL, and t(11;19)(q23;p13.3) MLL/MLLT1.

 

When an IGH rearrangement is identified, reflex testing is performed to using a CRLF2/IGH probes to identify a t(X;14)(p22.3;q32.33) and t(Y;14)(p11.32;q32.33)

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Fluorescence In Situ Hybridization (FISH)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

ALL (B-Cell), FISH

Aliases Lists additional common names for a test, as an aid in searching

+4,+10, +17
11q23 (MLL)
14q32 (IGH)
Acute Lymphoblastic Leukemia (ALL)
Adult Acute Lymphoblastic Leukemia (ALL)
CDKN2A/Cen9
del(9p) (p16)
Hyperdiploidy
p16
Pediatric Acute Lymphoblastic Leukemia (ALL)
t(1;19) (PBX1/TCF3)
t(12;21) (TEL/AML1)
t(9;22) (BCR/ABL)
TEL/AML1
ETV6/RUNX1
CRLF2/IGH
t(X;14)(p22.3;q32.33)
t(Y;14)(p11.32;q32.33)
t(4;11)(q21;q23) (AFF1/MLL)
t(9;11)(p22;q23) (MLLT3/MLL)
t(11;19)(q23;p13.1) (MLL/ELL)
t(11;19)(q23;p13.3) (MLL/MLLT1)
TP53