Unit Code 81596:
Glutamic Acid Decarboxylase (GAD65) Antibody Assay, Serum
Useful For 
Suggests clinical disorders or settings where the test may be helpful
Assessing susceptibility to autoimmune (type 1, insulin-dependent)
diabetes mellitus and related endocrine disorders (eg, thyroiditis and
pernicious anemia). Titers generally <20 nmol/L. A second islet cell
antibody, IA-2, is more predictive for development of type 1 diabetes,
but less frequent than GAD65 Ab amongst diabetic patients. Insulin
autoantibodies also serve as a marker of susceptibility to type 1 diabetes.
Distinguishing between patients with type 1 and type 2 diabetes. Assays
for IA-2, insulin, gastric parietal cell, thyroglobulin, and thyroid peroxidase
antibodies, complement GAD65 antibody in this context. Titers generally
<20 nmol/L.
Confirming a diagnosis of stiff-man syndrome, autoimmune encephalitis,
cerebellitis, brain stem encephalitis, myelitis. Titers generally >20 nmol/L.
Confirming susceptibility to organ-specific neurological disorders
(eg, myasthenia gravis, Lambert-Eaton syndrome). Titers generally
<20 nmol/L.
Method Name A short description of the method used to perform the test
Radioimmunoassay (RIA)
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
GAD65 Ab Assay, S
Ordering Mnemonic An alternate Mayo code (to the Unit Code) for a test
GAD65
Aliases Lists additional common names for a test, as an aid in searching
64K Antibody
Anti-GAD Antibodies
Anti-Glutamic Acid Decarboxylase Ab
Beta Cell Antibody
GAD65 Antibody Assay
Glutamate Decarboxylase Antibodies
Islet Cell Antibody (Mayo Alternative GAD65)
Pancreatic Islet Cell Ab
Soft-GD65S
Stiffman Syndrome
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