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Assessing the body pool size of oxalate. The settings in which it has been most useful include patients with enzyme deficiencies, such as primary hyperoxaluria, which result in overproduction of oxalate or patients with enteric hyperoxaluria (EH).
In the presence of chronic kidney disease (CKD), 3 uses of plasma oxalate are:
-If primary hyperoxaluria (PH) is suspected in a patient with CKD of indeterminate cause, and urinary oxalate is not available, plasma oxalate can be used to aid in diagnosis. However although plasma oxalate levels are markedly elevated in PH patients with CKD suggesting the diagnosis, ancillary tests often are necessary to confirm it, such as genetic analysis of the 3 causative genes, or pathologic demonstration of oxalate crystals in tissues
-Monitoring patients with renal failure and primary or enteric hyperoxaluria in order to be sure they are receiving enough dialysis
-An aid in maintaining plasma oxalate levels below supersaturation (25-30 mcmol/L)
See Hyperoxaluria Diagnostic Algorithm in Special Instructions.
Ion Chromatography (IC)