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Test Catalog

Test ID: MBCR    
BCR/ABL, Translocation 9;22, FISH (D-FISH)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Useful For Suggests clinical disorders or settings where the test may be helpful

Establishing the percentage of neoplastic interphase nuclei for patients with chronic myeloid leukemia (CML) at diagnosis and at all times during treatment, even in cytogenetic remission


Detecting all known forms of the Philadelphia (Ph) chromosome


Identifying and monitoring of the Ph chromosome in patients with CML, acute lymphocytic leukemia (ALL), or acute myeloid leukemia (AML)


It is recommended that conventional chromosome analysis BM / Chromosome Analysis, Hematologic Disorders, Bone Marrow also be performed at initial diagnosis. Subsequently, D-FISH alone can be used to monitor the effectiveness of therapy.

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, if further probes are needed, they will be added at an additional charge.


The following algorithms are available in Special Instructions:

-Myeloproliferative Neoplasm: A Diagnostic Approach to Peripheral Blood Evaluation

-Myeloproliferative Neoplasm: A Diagnostic Approach to Bone Marrow Evaluation

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Fluorescence In Situ Hybridization (FISH)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name


Aliases Lists additional common names for a test, as an aid in searching

9;22 translocation, FISH
Abelson Oncogene
BCR Major and Minor Breakpoints
Breakpoints Cluster Region
Chromosome Analysis Consultation, Fluorescent In Situ Hybridization with BCR/ABL
Chronic Myeloid Leukemia
FISH (Fluorescent In Situ Hybridization)
Fluorescence In Situ Hybridization (FISH) with BCR/ABL
Fluorescence In Situ Hybridization DNA Probes (D-FISH) with BCR/ABL
Fluorescent In Situ Hybridization (FISH)
Ph chromosome
Philadelphia Chromosome Ph1 Bone Marrow/Blood
t(9:22), FISH
Acute Lymphoblastic Leukemia (ALL)