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Unit Code 80013:
Paraneoplastic Autoantibody Evaluation, Spinal Fluid

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Useful For

As an aid in the diagnosis of paraneoplastic neurological autoimmune

disorders related to carcinoma of lung, breast, ovary, thymoma, or

Hodgkin's lymphoma

 

In patients with a history of tobacco use or other lung cancer risk, or if

thymoma is suspected, #83380 "Paraneoplastic Autoantibody Evaluation,

Serum" is also recommended.

Profile Information

 Unit Code  Reporting Name  Available Separately  Always Performed 
 3852   Anti-Neuronal Nuclear Ab, Type 1 No Yes
 7472   Anti-Neuronal Nuclear Ab, Type 2 No Yes
 21633   Anti-Neuronal Nuclear Ab, Type 3 No Yes
 89079  Anti-Glial Nuclear Ab, Type 1 No Yes
 3988   Purkinje Cell Cytoplasmic Ab Type 1 No Yes
 21632   Purkinje Cell Cytoplasmic Ab Type 2 No Yes
 21631   Purkinje Cell Cytoplasmc Ab Type Tr No Yes
 5906   Amphiphysin Ab, CSF No Yes
 21650   CRMP-5-IgG, CSF No Yes

Reflex Tests

 Unit Code  Reporting Name  Available Separately  Always Performed 
21764 Paraneoplas Autoantibody WBlot,CSF No No
21747 CRMP-5-IgG Western Blot, CSF No No
84221 GAD65 Ab Assay, CSF Yes No

Testing Algorithm

If IFA (3852, 7472, 21633, 3988, 21632, 21631, 5906, 21650, 89079)

is indeterminate, paraneoplastic autoantibody Western

blot is performed at an additional charge.

If client requests or if IFA patterns suggest CRMP-5-IgG, CRMP-5-IgG

Western blot is performed at an additional charge.

If IFA patterns suggest GAD65 antibody, GAD65 antibody radioimmuno-

precipitation assay is performed at an additional charge.

Method Name

3852, 7472, 21633, 3988, 21632, 21631, 5906, 21650, 89079: Indirect

Immunofluorescence Assay (IFA)

21764, 21747: Western Blot

84221: Radioimmunoprecipitation Assay

General Information:

CRMP-5-IgG Western blot is also performed by specific request

for more sensitive detection of CRMP-5-IgG. Testing should be

requested in cases of subacute basal ganglionic disorders (chorea,

Parkinsonism), cranial neuropathies (especially loss of vision,

taste, or smell), and myelopathies.

Reporting Name

Paraneoplastic Autoantib Eval, CSF

Ordering Mnemonic

PNEOE

Aliases

Amphiphysin Ab, CSF order 80013

ANNA-1, CSF order 80013

ANNA-2, CSF order 80013

ANNA-3, CSF order 80013

Anti-Hu

Anti-Yo

Antineuronal

Cerebellar Antibodies

CRMP-5-IgG, CSF order 80013

Dorsal Root Ganglion Antibody

Hu Antibody

Neuron Restricted Autoantibodies

Neuronal Nuclear Antibody

Neuronal-Anti

Ovarian Cancer-Related Antibodies

Paraneoplastic Autoantibody Western Blot Confirmation, CSF

Paraneoplastic Neurological Autoimmunity

PCA-1, CSF order 80013

PCA-2, CSF order 80013

PCA-Tr, CSF order 80013

Purkinje Cell Cytoplasmic Antibodies

Ri, Anti

Yo-Anti

Key