Test ID: PNEOE
Paraneoplastic Autoantibody Evaluation, Spinal Fluid
Secondary ID 
A test code used for billing and in test definitions created prior to November 2011
Useful For Suggests clinical disorders or settings where the test may be helpful
An aid in the diagnosis of paraneoplastic neurological autoimmune disorders related to carcinoma of lung, breast, ovary, thymoma, or Hodgkin's lymphoma.
In patients with a history of tobacco use or other lung cancer risk, or if thymoma is suspected, PAVAL/83380 Paraneoplastic Autoantibody Evaluation, Serum is also recommended.
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ANN1C | Anti-Neuronal Nuclear Ab, Type 1 | No | Yes |
| ANN2C | Anti-Neuronal Nuclear Ab, Type 2 | No | Yes |
| ANN3C | Anti-Neuronal Nuclear Ab, Type 3 | No | Yes |
| AGN1C | Anti-Glial Nuclear Ab, Type 1 | No | Yes |
| PCA1C | Purkinje Cell Cytoplasmic Ab Type 1 | No | Yes |
| PCA2C | Purkinje Cell Cytoplasmic Ab Type 2 | No | Yes |
| PCTRC | Purkinje Cell Cytoplasmc Ab Type Tr | No | Yes |
| AMPHC | Amphiphysin Ab, CSF | No | Yes |
| CRMC | CRMP-5-IgG, CSF | No | Yes |
Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)
| Test ID | Secondary ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|---|
| WBNC | 21764 | Paraneoplas Autoantibody WBlot,CSF | No | No |
| CRMWC | 21747 | CRMP-5-IgG Western Blot, CSF | No | No |
| GD65C | 84221 | GAD65 Ab Assay, CSF | Yes | No |
| NMOC | 83936 | NMO-IgG, CSF | Yes | No |
| ABLTC | 89380 | Amphiphysin Western Blot, CSF | No | No |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
If indirect immunofluorescence assay (IFA) (ANN1C/3852, ANN2C/7472, ANN3C/21633, PCA1C/3988, PCA2C/21632, PCTRC/21631, AMPHC/5906, CRMC/21650, AGN1C/89079) is indeterminate, paraneoplastic autoantibody Western blot is performed at an additional charge.
If IFA pattern is suggestive of neuromyelitis optica (NMO), then NMO-IgG is performed at an additional charge.
If client requests or if IFA patterns suggest CRMP-5-IgG, CRMP-5-IgG Western blot is performed at an additional charge.
If IFA patterns suggest GAD65 antibody, GAD65 antibody radioimmunoprecipitation assay is performed at an additional charge.
If IFA patterns suggest amphiphysin antibody, amphiphysin Western blot is performed at an additional charge.
Method Name A short description of the method used to perform the test
ANN1C/3852, ANN2C/7472, ANN3C/21633, PCA1C/3988, PCA2C/21632, PCTRC/21631, AMPHC/5906, CRMC/21650, AGN1C/89079, NMOC/83936: Indirect Immunofluorescence Assay (IFA)
WBNC/21764, CRMWC/21747, ABLTC/89380: Western Blot
GD65C/84221: Radioimmunoprecipitation Assay
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
Aliases Lists additional common names for a test, as an aid in searching
ANNA-1, CSF order 80013
ANNA-2, CSF order 80013
ANNA-3, CSF order 80013
Anti-Hu
Anti-Yo
Antineuronal
Cerebellar Antibodies
CRMP-5-IgG, CSF order 80013
Dorsal Root Ganglion Antibody
Hu Antibody
Neuron Restricted Autoantibodies
Neuronal Nuclear Antibody
Neuronal-Anti
Ovarian Cancer-Related Antibodies
Paraneoplastic Autoantibody Western Blot Confirmation, CSF
Paraneoplastic Neurological Autoimmunity
PCA-1, CSF order 80013
PCA-2, CSF order 80013
PCA-Tr, CSF order 80013
Purkinje Cell Cytoplasmic Antibodies
Ri, Anti
Yo-Anti
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