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Test ID: CALR    
CALR Mutation Analysis, Myeloproliferative Neoplasm (MPN)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Conditional

Useful For Suggests clinical disorders or settings where the test may be helpful

Rapid and sensitive detection of insertion and deletion-type mutations in exon 9 of CALR

 

An aid in distinction between reactive thrombocytosis and/or leukocytosis versus a myeloproliferative neoplasm (MPN), especially essential thrombocythemia (ET) and primary myelofibrosis (PMF), and is highly informative in cases in which JAK2 and MPL testing are negative

 

Especially helpful to the pathologist in those bone marrow cases with ambiguous etiology of thrombocytosis, equivocal bone marrow morphologic findings of MPN, and/or unexplained reticulin fibrosis

 

An aid in prognostication of PMF and thrombosis risk assessment in ET.

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

The following algorithms are available in Special Instructions:

-Myeloproliferative Neoplasm: A Diagnostic Approach to Peripheral Blood

-Myeloproliferative Neoplasm: A Diagnostic Approach to Bone Marrow Evaluation

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) and Fragment Analysis

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

MPN, CALR Gene Mutation, Exon 9

Aliases Lists additional common names for a test, as an aid in searching

Calreticulin
Myeloproliferative Neoplasm (MPN)
Myeloproliferative Disorder
Essential Thrombocythemia
Primary Myelofibrosis
Myelofibrosis
JAK2-negative Myeloproliferative Neoplasm
CALR