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Test ID: 2D6CB    
Cytochrome P450 2D6 (CYP2D6) Comprehensive Cascade, Blood

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Useful For Suggests clinical disorders or settings where the test may be helpful

Providing information relevant to tamoxifen codeine, and tramadol, as well as other medications metabolized by CYP2D6


Determining the exact genotype when other methods fail to generate this information or if genotype-phenotype discord is encountered clinically


Identifying exact genotyping when required (eg, drug trials, research protocols)


Identifying novel variants that may interfere with drug metabolism

Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request

Approximately 94% to 96% of individuals will not need additional CYP2D6 testing beyond tier 1. Based on tier 1 test sensitivity and CYP2D6 variant carrier frequencies, approximately 4% to 6% of Caucasians require testing through tier 2 or 3 in order to determine the comprehensive genotype (the frequency may be higher or lower in other ethnic groups). Testing through tier 3 allows for the detection of all common CYP2D6 variants (eg, *2, *3, *4, *5, *6, *7, *8, *9, *10, *17, *19, *29, *35, *41, *1XN, *2XN, *4XN) and rarer (including novel) alleles such as *11, *12, *14 and *15. Unitary and tandem CYP2D7-2D6 (*13) alleles and CYP2D6-2D7 (eg, *4N and *36) alleles can also be detected. Furthermore, the actual alleles that are duplicated or multiplied can be determined in most cases.

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
2D6CNCYP2D6 Copy Number Variation, BNo, (Bill Only)No
2D6X12D6CN Plus One SequenceNo, (Bill Only)No
2D6X22D6CN Plus Two SequencesNo, (Bill Only)No
2D6X32D6CN Plus Three SequencesNo, (Bill Only)No
2D6X42D6CN Plus Four SequencesNo, (Bill Only)No
2D6X52D6CN Plus Five SequencesNo, (Bill Only)No
2D6X62D6CN Plus Six SequencesNo, (Bill Only)No

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Tier 1: Polymerase Chain Reaction (PCR) with Allele-Specific Primer Extension (ASPE)

Tier 2: Real-Time Quantitative PCR
Tier 3: PCR followed by DNA Sequence Analysis

(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

CYP2D6 Genotype Cascade, B

Aliases Lists additional common names for a test, as an aid in searching

P450 Genotyping
Treatment Resistant Depression Panel
Breast Cancer Therapy
CYP2D6 for Breast Cancer