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Test ID: HIVDI    
HIV-1 and HIV-2 Antibody Differentiation, Serum

Secondary ID A test code used for billing and in test definitions created prior to November 2011


NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Useful For Suggests clinical disorders or settings where the test may be helpful

Detection and differentiation of HIV-1 and HIV-2 antibodies


Follow-up testing of specimens that are reactive by FDA-approved HIV antigen and antibody combination or HIV-1/-2 antibody immunoassays

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
HV1WBHIV-1 Ab Confirm by Western Blot, SYesNo
HIV2LHIV-2 Ab Confirmation, SYesNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

This HIV-1 and HIV-2 antibody differentiation test begins with the Bio-Rad Multispot HIV-1/HIV-2 Rapid Test, with the following reflex testing. Specimens with indeterminate HIV-1 antibody but negative HIV-2 antibody results then HIV-1 antibody confirmation by Western blot is performed at an additional charge. Specimens with reactive or unreadable results for both HIV-1 and HIV-2 antibodies then HIV-1 antibody confirmation by Western blot and HIV-2 antibody confirmation are performed at additional charges. For specimens with negative HIV-1 antibody but reactive HIV-2 antibody results, HIV-2 antibody confirmatory test is performed at an additional charge.


No reflex testing is performed on specimens with a) positive HIV-1 antibody but negative HIV-2 antibody results, or b) negative HIV-1 and HIV-2 results.


See HIV Testing Algorithm (Fourth Generation Screening Assay) Including Follow-up of Reactive HIV Rapid Serologic Test Results in Special Instructions.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Membrane Immunoconcentration

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

HIV-1/-2 Ab Differentiation, S

Aliases Lists additional common names for a test, as an aid in searching

Acquired Immune Deficiency Syndrome (AIDS)
Anti-HIV-1/-2 Differentiation
HIV Types 1 and 2 Antibodies
HIV-1/-2 Ab
HIV-1/-2 Antibodies
HIV-1/-2 Antibody Differentiation
HIV Antibody Differentiation
Human Immunodeficiency Virus (HIV)