|Values are valid only on day of printing.|
Evaluating chronic lymphocytic leukemia patients at diagnosis or during disease course for the presence of TP53 gene mutations indicating high risk of disease progression and adverse outcome
This test is complementary to FISH analysis for the 17p- abnormality, but more appropriately identifies the presence of mutational alteration and gene inactivation in tumor cells. For hereditary (germ line) TP53 mutation syndrome testing, see TP53Z / TP53 Gene, Full Gene Analysis.
|Test ID||Reporting Name||Available Separately||Always Performed|
|CKP53||CKP53 Protocol, B||No||No|
Flow cytometry CKP53 / CKP53 Protocol, Blood may be performed on peripheral blood samples to verify diagnosis of chronic lymphocytic leukemia (CLL) and determine the % B-cells in the sample prior to TP53 testing. See TP53 Sequencing Testing Algorithm in Special Instructions.
Polymerase Chain Reaction (PCR) and Sanger Sequencing
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)