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Test ID: P53CA    
Hematologic Neoplasms, TP53 Somatic Mutation, DNA Sequencing Exons 4-9

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Conditional

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluating chronic lymphocytic leukemia patients at diagnosis or during disease course for the presence of TP53 gene mutations indicating high risk of disease progression and adverse outcome.

 

This test is complementary to FISH analysis for the 17p- abnormality, but more appropriately identifies the presence of mutational alteration and gene inactivation in tumor cells. For hereditary (germ line) TP53 mutation syndrome testing, see P53MS / TP53 Gene, Full Gene Analysis.

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
CKP53CKP53 Protocol, BNoNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

Flow cytometry CKP53 / CKP53 Protocol, Blood may be performed on peripheral blood samples to verify diagnosis of chronic lymphocytic leukemia (CLL) and determine the % B-cells in the sample prior to TP53 testing. See TP53 Sequencing Testing Algorithm in Special Instructions.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) and Sanger Sequencing

(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

TP53 gene somatic mutation analysis

Aliases Lists additional common names for a test, as an aid in searching

TP53
P53
CLL
BCLL