ANAR - Overview: Antinuclear Antibodies (ANA), IFA with Reflex to Connective Tissue Disease Antibodies

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Test ID: ANAR    
Antinuclear Antibodies (ANA), IFA with Reflex to Connective Tissue Disease Antibodies

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluation of patients with signs and symptoms compatible with connective tissue diseases


The testing algorithm is useful in the initial evaluation of patients and performs best in clinical situations in which the prevalence of disease is low.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
ANAH2Antinuclear Ab, HEp-2 Substrate, SYesYes

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
ANABAntinuclear Antibody (Multiple), SNoNo
ADNADNA Double-Stranded Ab, IgG, SYesNo
RIBRibosome P Ab, IgG, SYesNo
ENAEAb to Extractable Nuclear Ag Eval,SYesNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If antinuclear antibodies (ANA) HEp-2 substrate screen is positive, then ANA multiple will be performed at an additional charge.

If ANAB is <1:160, the cascade will stop and results will be reported.

If ANAB is > or =1:160, then DNA double-stranded antibody, ribosome P antibody, and antibody to extractable nuclear antibody will be performed at an additional charge.

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Immunofluorescence Assay (IFA)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

ANA Reflex to CTD Ab, S

Aliases Lists additional common names for a test, as an aid in searching

U(1)RNP (Ribonucleoprotein) Autoantibodies
Topoisomerase 1 Antibodies
Tissue, Connective
Systemic Lupus Erythematosus (SLE)
SSB (Anti-SSB)
SSA (Anti-SSA)
SmRNP Autoantibodies
Smith Antigen, Anti
Sm (Anti-Sm) Smith
SLE (Systemic Lupus Erythematosus)
Sjogren's Syndrome
Scleroderma Antibodies
Scl 70 Antibodies
Ro (Anti-SSA)
RNA (Ribonucleoprotein) Autoantibodies)
Ribonucleoprotein (RNP) Autoantibodies
Polymyositis Antibodies
Lupus Erythematosus (LE)
LE (Lupus Erythematosus)
La (Anti-SSB)
Jo 1 Antibodies
Histidyl-tRNA Synthetase Antibodies
FANA (Fluorescent Antinuclear Antibodies)
Extractable Nuclear Antigens, Anti
ENA (Extractable Nuclear Antigens), Anti
DNA, Anti
DNA Topoisomerase 1 Antibodies
DNA Double-Stranded (ds-DNA) Antibody
Connective Tissue
Autoantibodies to U(1)RNP
Autoantibodies to SSB (La)
Autoantibodies to SSA (Ro)
Autoantibodies to Sm (Smith)
Autoantibodies to Scl 70 Antigen
Autoantibodies to Scl 70
Autoantibodies to Jo1
Autoantibodies to Jo 1 Antigen
Antinuclear Antibody
Antinuclear Antibodies (ANA)
Antibody to Native DNA (n-DNA)
Antibodies to Extractable Nuclear Antigens
Anti-U(1)RNP (Anti-Ribonucleoprotein)
Anti-SSB (Anti-Sjogren's Syndrome B)
Anti-SSA (Anti-Sjogren's Syndrome A)
Anti-Smith (Sm) Antigen
Anti-Sm (Smith)
Anti-Sjogren's Syndrome
Anti-RNP (Anti-Ribonucleoprotein)
Anti-Ribosome P Antibodies
Anti-Ribonuclear Protein
Anti-ENA (Antibodies to Extractable Nuclear Antigens)
Anti-ds (Anti-Double-Stranded) DNA
ANA Test algorithm
ANA Reflex Testing
ANA (Antinuclear Antibodies)