Mobile Site ›
Print Friendly View

Test ID: ENCEC    
Encephalopathy, Autoimmune Evaluation, Spinal Fluid

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea, vomiting, inappropriate antidiuresis, coma, dysautonomias, or hypoventilation

 

The following accompaniments should increase of suspicion for autoimmune encephalopathy:

-Headache

-Autoimmune stigmata (personal or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)

-History of cancer

-Smoking history (20+ pack years) or other cancer risk factors

-Inflammatory cerebral spinal fluid (or isolated protein elevation)

-Neuroimaging signs suggesting inflammation

 

Evaluating limbic encephalitis (noninfectious)

 

Directing a focused search for cancer

 

Investigating encephalopathy appearing in the course or wake of cancer therapy and not explainable by metastasis or drug effect

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
AEECIEncephalopathy, Interpretation, CSFNoYes
NMDCCNMDA-R Ab CBA, CSFNoYes
VGKCCVGKC-complex Ab IPA, CSFNoYes
GD65CGAD65 Ab Assay, CSFYesYes
GABCCGABA-B-R Ab CBA, CSFNoYes
AMPCCAMPA-R Ab CBA, CSFNoYes
ANN1CAnti-Neuronal Nuclear Ab, Type 1NoYes
ANN2CAnti-Neuronal Nuclear Ab, Type 2NoYes
ANN3CAnti-Neuronal Nuclear Ab, Type 3NoYes
AGN1CAnti-Glial Nuclear Ab, Type 1NoYes
PCA1CPurkinje Cell Cytoplasmic Ab Type 1NoYes
PCA2CPurkinje Cell Cytoplasmic Ab Type 2NoYes
PCTRCPurkinje Cell Cytoplasmc Ab Type TrNoYes
AMPHCAmphiphysin Ab, CSFNoYes
CRMCCRMP-5-IgG, CSFNoYes

Reflex Tests Lists test(s) that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial test(s)

Test IDReporting NameAvailable SeparatelyAlways Performed
WBNCParaneoplas Autoantibody WBlot,CSFNoNo
CRMWCCRMP-5-IgG Western Blot, CSFNoNo
ABLTCAmphiphysin Western Blot, CSFNoNo
NMOCCNMO/AQP4-IgG CBA, CSFYesNo
AMPICAMPA-R Ab IF Titer Assay, CSFNoNo
GABICGABA-B-R Ab IF Titer Assay, CSFNoNo
NMDICNMDA-R Ab IF Titer Assay, CSFNoNo

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If indirect immunofluorescence assay (IFA) (ANN1C, ANN2C, ANN3C, AGN1C, PCA2C, PCTRC, AMPHC, CRMC) is indeterminate, then WBNC is performed at an additional charge.

If client requests or if IFA patterns suggest CRMP-5-IgG, then CRMWC is performed at an additional charge.

If IFA pattern suggest amphiphysin antibody, then ABLTC is performed at an additional charge.

If IFA pattern suggest NMO/AQP4-IgG, then NMOCC is performed at an additional charge.

If IFA pattern suggest AMPA-R Ab and AMPCC is positive, then AMPIC is performed at an additional charge.

If IFA pattern suggest GABA-B-R Ab and GABCC is positive, then GABIC is performed at an additional charge.

If IFA pattern suggest NMDA-R Ab and NMDCC is positive, then NMDIC is performed at an additional charge.

 

See Encephalopathy Autoimmune Evaluation Algorithm, Spinal Fluid in Special Instructions

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

ANN1C, ANN2C, ANN3C, AGN1C, PCA1C, PCA2C, PCTRC, AMPHC, CRMC, AMPIC, GABIC, NMDIC: Indirect Immunofluorescence Assay (IFA)

AMPCC, GABCC, NMDCC: Cell-Binding Assay (CBA)

GD65C: Immunoprecipitation Assay

VGKCC: Radioimmunoassay (RIA)

WBNC, CRMWC, ABLTC: Western Blot

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Encephalopathy-Autoimmune Eval, CSF

Aliases Lists additional common names for a test, as an aid in searching

Anti-Neuronal Nuclear Antibody, Type 1
Anti-Neuronal Nuclear Antibody, Type 2
Anti-Neuronal Nuclear Antibody, Type 3
Anti-Glial Nuclear Antibody, Type 1
Purkinje Cell Cytoplasmic Antibody, Type 1
Purkinje Cell Cytoplasmic Antibody, Type 2
Purkinje Cell Cytoplasmic Antibody, Type Tr
Amphiphysin Antibody
CRMP-5-IgG
AMPA-R Antibody CBA
GABA-B-R Antibody CBA
NMDA-R Antibody CBA
Glutamic Acid Decarboxylase (GAD65)
VGKC-Complex Antibody IPA
Confusion
Encephalitis
Behavioral Change
Psychosis
ENCEC_x