UGTIO - Overview: UDP-Glucuronosyl Transferase 1A1 (UGT1A1), Full Gene Sequencing, Irinotecan Hypersensitivity, Saliva

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Test ID: UGTIO    
UDP-Glucuronosyl Transferase 1A1 (UGT1A1), Full Gene Sequencing, Irinotecan Hypersensitivity, Saliva

Useful For Suggests clinical disorders or settings where the test may be helpful

Identifying individuals who are at increased risk of adverse drug reactions with drugs that are metabolized by UGT1A1, including irinotecan, atazanavir, nilotinib, pazopanib, and belinostat.


Genotyping patients who prefer not to have venipuncture done

Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request

This test includes gene sequencing of UGT1A1 and the results are interpreted for the purposes of UGT1A1 drug metabolism. If UGT1A1 gene sequencing is desired for interpretation related to hyperbilirubinemia syndromes including Gilbert syndrome and Crigler-Najjar syndrome, order UGT2O / UDP-Glucuronosyl Transferase 1A1 (UGT1A1), Full Gene Sequencing, Hyperbilirubinemia, Saliva.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
UGT1OUGT1A1 Gene Sequence, IrinotecanNoYes
UGTSQUGT, Full Gene SequencingNoYes

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

See UGT1A1 Test-Ordering Algorithm in Special Instructions

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) Followed by Gene Sequencing

(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

UGT1A1 Sequence, Irinotecan, Saliva

Aliases Lists additional common names for a test, as an aid in searching

Irinotecan glucuronidation
Irinotecan metabolism
Phenol/Bilirubin UDP-Glucuronosyltransferase
UDP-Glucosyltransferase 1
Uracil Glucuronyl transferase
Uridine Diphosphate Glucosyltransferase 1