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Test ID: HTR2O    
Serotonin Receptor Genotype (HTR2A and HTR2C), Saliva

Available on the App Store

NY State Approved Indicates the status of NY State approval and if the test is orderable for NY State clients.


Useful For Suggests clinical disorders or settings where the test may be helpful

Guiding treatment choice of an (selective serotonin reuptake inhibitor) SSRI or non-SSRI antidepressant. Individuals homozygous for the IVS2+54538 A allele have improved probability of response to citalopram, in contrast to individuals homozygous or heterozygous for the IVS2 G allele. Individuals with major depression disorders are more likely to respond to citalopram if they are homozygous for the -1438G promoter allele.


Guiding treatment choice in individuals who have a drug-metabolizer phenotype discordant with CYP450 genotypes


Identifying patients who may benefit from treatment with the antipsychotic drug clozapine


Identifying those patients receiving atypical antipsychotic medications with excessive weight gain who may benefit by switching to different antipsychotic medications


Genotyping patients who prefer not to have venipuncture done

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.


Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test

Method Name A short description of the method used to perform the test

Polymerase Chain Reaction (PCR) with Allele-Specific Primer Extension (ASPE)
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name

Serotonin Receptor 2A/2C, Saliva

Aliases Lists additional common names for a test, as an aid in searching

Serotonin Receptor HTR
Type 2 Serotonin Receptor 5HT