Test ID: LCMS    
Leukemia/Lymphoma Immunophenotyping by Flow Cytometry

Evaluating lymphocytoses of undetermined etiology

Identifying B- and T-cell lymphoproliferative disorders involving blood and bone marrow

Distinguishing acute lymphoblastic leukemia (ALL) from acute myeloid leukemia (AML)

Immunologic subtyping of ALL

Distinguishing reactive lymphocytes and lymphoid hyperplasia from malignant lymphoma

Distinguishing between malignant lymphoma and acute leukemia

Phenotypic subclassification of B- and T-cell chronic lymphoproliferative disorders, including chronic lymphocytic leukemia, mantle cell lymphoma, and hairy cell leukemia

Recognizing AML with minimal morphologic or cytochemical evidence of differentiation

Recognizing monoclonal plasma cells

When a blood, bone marrow, or fluid test is ordered, a screening panel and a professional interpretation will always be charged. The screening panel will be charged based on number of markers tested (80997 for first marker, 81047 for each additional marker). The interpretation will be based on markers tested in increments of 2 to 8, 9 to 15, or 16 and greater. In addition, reflex testing may occur to fully characterize a disease state or clarify any abnormalities from the screening test. Reflex tests will be performed at an additional charge for each marker tested (80997 if applicable, 81047 if applicable).

Note: FISH or molecular testing may be recommended by the Mayo pathologist in some cases. They will contact the referring physician or pathologist to confirm the addition of these tests.

The following algorithms are available in Special Instructions:

-Malignant Lymphoma, Guideline for Bone Marrow Staging Studies

-Acute Promyelocytic Leukemia: Guideline to Diagnosis and Follow-up

• Hematopathology Patient Information Sheet
• Malignant Lymphoma, Guideline for Bone Marrow Staging Studies
• Acute Promyelocytic Leukemia: Guideline to Diagnosis and Follow-up

Flow Cytometry

Includes flow cytometric analysis with an assortment of lymphocyte- and/or myeloid-lineage associated antigens. The appropriate selection of these is chosen by a Mayo Hematopathologist based on clinical information, specimen type, specimen volume, cellular characteristics, and/or morphologic review, keeping in mind the clinical impression of the referring physician. This test also includes review of morphology for quality correlation with immunophenotypic results.

Note: This procedure is applicable for cases of acute lymphoblastic leukemia, acute myelogenous leukemia, chronic lymphoproliferative disorders, and malignant lymphomas.