Unit Code 17073:
Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Screen
Useful For 
Suggests clinical disorders or settings where the test may be helpful
Identification of individuals at high risk for having Lynch syndrome
Genetics Test Information Provides information that may help with selection of the correct test or proper submission of the test request
Both microsatellite instability (MSI) and immunohistochemistry
(IHC) testing of tumor tissue from an affected individual are
performed to screen individuals for possible HNPCC.
Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Unit Code. Profile information lists tests performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.
| Unit Code | Reporting Name | Available Separately | Always Performed |
| 82500 | Microsatellite Instability, Tumor | Yes (Order #88566) | Yes |
| 29004 | MMR Protein, IHC Only, Tumor | Yes | Yes |
Additional Tests Lists test(s) that are always performed, at an additional charge, with the initial test(s)
| Unit Code | Reporting Name | Available Separately | Always Performed |
| 29234 | Slide Review, Mol Gen | No | Yes |
| 29005 | MLH-1, Immunostain | No | Yes |
| 29006 | MSH-2, Immunostain | No | Yes |
| 29007 | MSH-6, Immunostain | No | Yes |
| 29008 | PMS-2, Immunostain | No | Yes |
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
When this test is ordered, slide review, MLH1, MSH2, MSH6, and PMS2
stains will always be performed at an additional charge.
Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test
| • | Molecular Genetics - Inherited Cancer Syndromes Patient Information Sheet |
| • | Informed Consent for DNA Testing |
| • | Hereditary Nonpolyposis Colorectal Cancer Testing Algorithm |
Method Name A short description of the method used to perform the test
82500: A polymerase chain reaction (PCR)-based assay is
used to test for tumor microsatellite instability with the use of
five mononucleotide repeats.
(PCR is utilized pursuant to a license agreement with Roche
Molecular Systems, Inc.)
29005, 29006, 29007, 29008:
Immunohistochemistry is used to test for the presence of
the following proteins: hMLH1, hMSH2, hMSH6, and PMS2.
General Information:
See "Hereditary Nonpolyposis Colorectal Cancer Testing
Algorithm" in Special Instructions.
Reporting Name A shorter/abbreviated version of the Published Name for a test; an abbreviated test name
HNPCC Screen
Ordering Mnemonic An alternate Mayo code (to the Unit Code) for a test
HNPCC
Aliases Lists additional common names for a test, as an aid in searching
DNA Mismatch Repair-related HNPCC
Hereditary Nonpolyposis Colon Cancer (HNPCC)
HNPCC (Hereditary Nonpolyposis Colon Cancer)
IHC (Immunohistochemistry)
Immunohistochemistry (IHC)
Lynch Syndrome
Microsatellite Instability (MSI)
MSI (Microsatellite Instability)
Soft-HNPCC
Tumor Microsatellite Instability (MSI)
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