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Test ID: HNPCC    
Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Screen

Fees Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

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Test Classification Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer's instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR), Investigation Use Only (IUO) product, or a Research Use Only (RUO) product.

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Medical Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

81301-Microsatellite instability analysis (eg, hereditary non-polyposis colorectal cancer, Lynch syndrome) of markers for mismatch repair deficiency (eg, BAT25, BAT26), includes comparison of neoplastic and normal tissue, if performed

MLH-1, Immunostain

88341 (if appropriate)


MSH-2, Immunostain

88341 (if appropriate)


MSH-6, Immunostain

88341 (if appropriate)


PMS-2, Immunostain

88342 (if appropriate)


88381-Microdissection, manual

LOINC® Code Information Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the result codes returned for this test or profile.

Result IDReporting NameLOINC Code
17156Specimen IDN/A
29686Specimen IDN/A
17158Order DateN/A
29688Order DateN/A
29689Reason For Referral42349-1
17160Reason For Referral42349-1
29691MLH1 IHC50322-7
29692MSH2 IHC50323-5
29693MSH6 IHC50324-3
29383Extraction Performed?N/A
29694PMS2 IHC50328-4
29695ResultIn Process
17165Report DateN/A
29697AmendmentIn Process
29698Reviewed By:N/A
29699Release DateN/A

LOINC and CPT codes are provided by the performing laboratory.