Mobile Site ›
Print Page Email Page
Print Friendly View

Test ID: FCHAB    
Chromatin Antibodies, ELISA

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

REFERENCE RANGE:  <20 units

 

 INTERPRETIVE CRITERIA:

<20 units Antibodies not detected

> or = 20 units Antibodies detected

 

 Antibodies to chromatin (DNA complexed with histone proteins) are found in >50% of patients with systemic lupus erythematosus (SLE), and are significantly associated with kidney disease in this patient group. Among patients with autoimmune connective tissue diseases, detection of chromatin antibodies is 95% specific for SLE; in addition, chromatin antibodies are also more sensitive and specific than histone antibodies for identifying patients with drug-induced lupus. Recent studies further demonstrate that chromatin antibodies are present in about 40% of patients with autoimmune hepatitis, and identify patients with active disease who commonly relapse after drug withdrawal. Other names used for chromatin antibodies include LE-cell factor, DNP antibodies, and (H2A-H2B)-DNA antibodies.

 

Test Performed by: Focus Diagnostics, Inc.

                                       5785 Corporate Ave

                                       Cypress, CA 90630-4750