Chromatin Antibodies, ELISA
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
REFERENCE RANGE: <20 units
<20 units Antibodies not detected
> or = 20 units Antibodies detected
Antibodies to chromatin (DNA complexed with histone proteins) are found in >50% of patients with systemic lupus erythematosus (SLE), and are significantly associated with kidney disease in this patient group. Among patients with autoimmune connective tissue diseases, detection of chromatin antibodies is 95% specific for SLE; in addition, chromatin antibodies are also more sensitive and specific than histone antibodies for identifying patients with drug-induced lupus. Recent studies further demonstrate that chromatin antibodies are present in about 40% of patients with autoimmune hepatitis, and identify patients with active disease who commonly relapse after drug withdrawal. Other names used for chromatin antibodies include LE-cell factor, DNP antibodies, and (H2A-H2B)-DNA antibodies.
Test Performed by: Focus Diagnostics, Inc.
5785 Corporate Ave
Cypress, CA 90630-4750