Prometheus Thiopurine Metabolites
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Units of Measure: pmol/8 x 10(8) RBC
Metabolite Reference Range
Proprietary and patented technology by Prometheus Laboratories, Inc. The therapeutic range and toxic thresholds were established in an IBD patient population receiving azathioprine or 6-mercaptopurine. Metabolite testing should not replace laboratory monitoring for toxicity.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Dubinsky M, et al. Pharmacogenomics and metabolite
measurement for 6-mercaptopurine therapy in patients with
inflammatory bowel disease. Gastroenterology. 2000;118:705-713.
Seidman EG. Recent Advances in the diagnosis and treatment
of pediatric inflammatory bowel disease. Gastroenterol Rep.2000;
Cuffari C, et al. Utilisation of erythrocyte 6-thioguanine metabolite
levels to optimize azathioprine therapy in patients with inflammatory
bowel disease. Gut. 2001;48:642-646.
Seidman, EG. Clinical use and practical application of TPMT Enzyme
and 6-mercaptopurine metabolite monitoring in IBD. Rev
Gastroenterol Disord. 2003;3(suppl 1):S30-S38.
Rumbo C, et al. Azathioprine metabolite measurements in the
treatment of autoimmune hepatitis in pediatric patients: A preliminary
report. J Ped Gastro Nutr. 2002;35:391-398.
Lennard L, et al. The clinical pharmacology of 6-mercaptopurine.
Eur J Clin Pharmacol. 1992;43(4):329-339.
Lennard L. Clinical implication of thiopurine methyltransferase-Optimization
of drug dosage and potential drug interactions. Ther Drug Monit 1998;
Louis E, Belaiche J. Optimizing treatment with thioguanine derivative
in inflammatory bowel disease. Best Pract Res Clin Gastroenterol