FPTHC - Clinical: PTH Accuratio Comprehensive Profile

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Test ID: FPTHC    
PTH Accuratio Comprehensive Profile

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

COMPREHENSIVE PROFILE

   

TOTAL PTH Reference Range:     14.0 - 66.0 pg/mL

CAP PTH Reference Range:             5.0 - 39.0 pg/mL

CIP VALUE Reference Range:         2.5 - 29.0 pg/mL

CAP/CIP Reference Range:              1.1 - 6.9 ratio

 

Low ratio or PTH values are associated with Adynamic bone turnover status for an ESRD patient.

 

Total PTH:

Total Intact PTH is the sum of CAP PTH and N-truncated PTH fragment (likely 7-84) Total PTH = Intact PTH = CAP + CIP.

FDA approved.

 

CAP PTH:

CAP stands for Cyclase Activating PTH and is the same as Whole PTH which is 1-84 PTH and which raises bone turnover.

FDA approved.

 

CIP VALUE:

CIP stands for Cyclase Inactive PTH and the N-truncated PTH fragment, likely 7-84 PTH. CIP = Total PTH – CAP.

 

CAP/CIP:

CAP/CIP ratio is a calculated value and has been shown to be 93% predictive of bone turnover for the ESRD patient, however, bone biopsy is 100% predictive, therefore, clinical correlation is recommended.

  

 

Reference ranges were established using a 95% reference interval on a normal population with normal functioning kidneys. These reference ranges should not be applied to ESRD patients with impaired or non-functioning renal function.

Clinical Reference Provides recommendations for further in-depth reading of a clinical nature

REFERENCES:

CAP reference range 90-170 pgm/mL & Ratio <1.4 = Adynamic

Bone Disease

         Tokumoto, A J Amer Soc Nephrol 2003 (Nov); 14:702

         Tokumoto, A J Amer Soc Nephrol 2003 (Nov); 14:700

CAP/CIP Ratio 93% predictive:

          Faugere M-C, Geng Z, Mawad H, Friedler RM, Gao P,

          Cantor T, Malluche H. Kidney Int 2001; 60: 1460-1468.

Total PTH>1000 pg/mL & RATIO <or=1.4=High Bone Turnover

           American Journal of Kidney Diseases, Vol 26, No4 (Oct),

           1995: pp622-31

  

 

TEST PERFORMED BY:  

SCANTIBODIES CLINICAL LABORATORY, INC.

9236 ABRAHAM WAY

SANTEE, CA  92701

 

 


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