PTH Accuratio Comprehensive Profile
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
TOTAL PTH Reference Range: 14.0 - 66.0 pg/mL
CAP PTH Reference Range: 5.0 - 39.0 pg/mL
CIP VALUE Reference Range: 2.5 - 29.0 pg/mL
CAP/CIP Reference Range: 1.1 - 6.9 ratio
Low ratio or PTH values are associated with Adynamic bone turnover status for an ESRD patient.
Total Intact PTH is the sum of CAP PTH and N-truncated PTH fragment (likely 7-84) Total PTH = Intact PTH = CAP + CIP.
CAP stands for Cyclase Activating PTH and is the same as Whole PTH which is 1-84 PTH and which raises bone turnover.
CIP stands for Cyclase Inactive PTH and the N-truncated PTH fragment, likely 7-84 PTH. CIP = Total PTH – CAP.
CAP/CIP ratio is a calculated value and has been shown to be 93% predictive of bone turnover for the ESRD patient, however, bone biopsy is 100% predictive, therefore, clinical correlation is recommended.
Reference ranges were established using a 95% reference interval on a normal population with normal functioning kidneys. These reference ranges should not be applied to ESRD patients with impaired or non-functioning renal function.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
CAP reference range 90-170 pgm/mL & Ratio <1.4 = Adynamic
Tokumoto, A J Amer Soc Nephrol 2003 (Nov); 14:702
Tokumoto, A J Amer Soc Nephrol 2003 (Nov); 14:700
CAP/CIP Ratio 93% predictive:
Faugere M-C, Geng Z, Mawad H, Friedler RM, Gao P,
Cantor T, Malluche H. Kidney Int 2001; 60: 1460-1468.
Total PTH>1000 pg/mL & RATIO <or=1.4=High Bone Turnover
American Journal of Kidney Diseases, Vol 26, No4 (Oct),
TEST PERFORMED BY:
SCANTIBODIES CLINICAL LABORATORY, INC.
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