Test ID: FMENE
Meningoencephalitis (Encephalitis) Panel, CSF

Herpes Simplex Virus   (IgG) Type-Specific Antibodies (CSF)

   Reference Range:  

      < or = 1.00

  Interpretive Criteria:

     < or = 1.00 Antibody Not Detected

              > 1.00  Antibody Detected

 

Detection of HSV type-specific IgG in CSF may indicate central

nervous system (CNS) infection by that HSV type.  However,

interpretation of results may be complicated by a number of

factors, including low antibody levels found in CSF, passive transfer

of antibody across the blood-brain barrier, and serum contamination

of CSF during CSF collection.  PCR detection of type-specific HSV

DNA in CSF is the preferred method for identifying HSV CNS infections.  

 

Herpes Simplex Virus (HSV) 1/2 IgM Antibody, IFA (CSF)

Reference Range:

  <1:1

Interpretive Criteria:

        <1:1 Antibody Not Detected

  >or=1:1 Antibody Detected

  

The IFA procedure for measuring IgM antibodies to HSV1 and

HSV2 detects both type-common and type-specific HSV

antibodies. Thus, elevated titers to both HSV1 and HSV2 may

represent crossreactive HSV antibodies rather than exposure

to both HSV1 and HSV2.

  

The intrathecal synthesis of HSV antibody is most accurately

measured by performing the Antibody Index for CNS Infection.

  

Diagnosis of central nervous system infections can be

accomplished by demonstrating the presence of

intrathecally-produced specific antibody. Interpreting

results may be complicated by low antibody levels found

in CSF, passive transfer of antibody from blood, and

contamination via bloody taps. The interpretation of CSF

results must consider CSF-serum antibody ratios to the

infectious agent.

 

This assay was developed and its performance characteristics

have been determined by Focus Diagnostics. It has not been cleared

or approved by the U.S. Food and Drug Administration. The FDA

has determined that such clearance or approval is not necessary.

Performance characteristics refer to the analytical performance of the test.

 

Mumps Antibody Panel, IFA (CSF)

Reference Range:

   IgG    <1:8

   IgM    <1:1

 

Diagnosis of infections of the central nervous system can

be accomplished by demonstrating the presence of

intrathecally-produced specific antibody. Interpretation of

results may be complicated by low antibody levels found

in CSF, passive transfer of antibody from blood, and

contamination via bloody taps. The interpretation of CSF

results must consider CSF-serum antibody ratios to the

infectious agent.

 

This assay was developed and its performance characteristics

have been determined by Focus Diagnostics. It has not been

cleared or approved by the U.S. Food and Drug Administration.

The FDA has determined that such clearance or approval is

not necessary. Performance characteristics refer to the analytical

performance of the test.

 

Lymphocytic Choriomeningitis (LCM) Virus Ab, IFA (CSF)

Reference Range:

   IgG    <1:1

   IgM    <1:1

  

Interpretive Criteria:

         <1:1 Antibody Not Detected

   >or=1:1 Antibody Detected

  

Diagnosis of infections of the central nervous system can

be accomplished by demonstrating the presence of

intrathecally-produced specific antibody. However, interpreting

results is complicated by low antibody levels found

in CSF, passive transfer of antibody from blood, and

contamination via bloody taps.

  

This assay was developed and its performance

characteristics determined by Focus Diagnostics. It has

not been cleared or approved by the U.S. Food and Drug

Administration. The FDA has determined that such

clearance or approval is not necessary. Performance

characteristics refer to the analytical performance of the test.

  

Eastern Equine Encephalitis Virus Antibody, IFA (CSF)

Reference Range:

   IgG    <1:4

   IgM    <1:4

  

Note:  Specimens positive for arbovirus antibody are CDC reportable.

              Please  contact your local public health agency.

    

Diagnosis of infections of the central nervous system can be

accomplished by demonstrating the presence of

intrathecally-produced specific antibody. However, interpreting

results is complicated by low antibody levels found

in CSF, passive transfer of antibody from blood, and

contamination via bloody taps. The interpretation of CSF results

must consider CSF-serum antibody ratios to the infectious agent.

  

California Encephalitis Virus Antibody Panel, IFA (CSF)

Reference Range:

   IgG    <1:4

   IgM    <1:4

  

Note:  Specimens positive for arbovirus antibody are CDC reportable.

              Please contact your local public health agency.

    

Diagnosis of infections of the central nervous system can be

accomplished by demonstrating the presence of

intrathecally-produced specific antibody. However, interpreting

results is complicated by low antibody levels found

in CSF, passive transfer of antibody from blood, and

contamination via bloody taps. The interpretation of CSF results

must consider CSF-serum antibody ratios to the infectious agent.

  

St. Louis Encephalitis Virus Antibody, IFA (CSF)

Reference Range:

   IgG    <1:4

   IgM    <1:4

  

Note:  Specimens positive for arbovirus antibody are CDC reportable.

              Please contact your local public health agency.

    

Diagnosis of infections of the central nervous system can be

accomplished by demonstrating the presence of

intrathecally-produced specific antibody. However, interpreting

results is complicated by low antibody levels found

in CSF, passive transfer of antibody from blood, and

contamination via bloody taps. The interpretation of CSF results

must consider CSF-serum antibody ratios to the infectious agent.

 

Western Equine Encephalitis IgG and IgM Ab Pnl, IFA (CSF)

Reference Range:

   IgG    <1:4

   IgM    <1:4

  

Note:  Specimens positive for arbovirus antibody are CDC reportable.

              Please contact your local public health agency.

    

Diagnosis of infections of the central nervous system can be

accomplished by demonstrating the presence of

intrathecally-produced specific antibody. However, interpreting

results is complicated by low antibody levels found

in CSF, passive transfer of antibody from blood, and

contamination via bloody taps. The interpretation of CSF results

must consider CSF-serum antibody ratios to the infectious agent.

  

  

Tests Performed By:  Focus Diagnostics, Inc.

                                           5785 Corporate Ave.

                                           Cypress, CA   90630-4750