Test ID: FMENC
Meningoencephalitis Comprehensive Panel (CSF)

California Encephalitis Virus Antibody Panel, IFA (CSF)

 Reference Range:  IgG  <1:4

                                               IgM  <1:4

 

NOTE: Specimens positive for arbovirus antibody are CDC reportable.

Please contact your local public health agency.

 

Diagnosis of infections of the central nervous system can be

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. However, interpreting results is

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

Eastern Equine Encephalitis Virus Antibody, IFA (CSF)

Reference Range:  IgG  <1:4

                                     IgM  <1:4

NOTE: Specimens positive for arbovirus antibody are CDC reportable.

 Please contact your local public health agency.

 

Diagnosis of infections of the central nervous system can be

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. However, interpreting results is

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

St. Louis Encephalitis Virus Antibody, IFA (CSF)

Reference Range:  IgG  <1:4

                                    IgM  <1:4

 

NOTE: Specimens positive for arbovirus antibody are CDC reportable.

Please contact your local  public health agency.

 

Diagnosis of infections of the central nervous system can be

accomplished  by demonstrating the presence of intrathecally-

produced specific antibody. However, interpreting results is

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

Western Equine Encephalitis IgG and IgM Pnl, IFA (CSF)

Reference Range:  IgG  <1:4

                                    IgM  <1:4

 

NOTE: Specimens positive for arbovirus antibody are CDC reportable.

Please contact your local public health agency.

 

Diagnosis of infections of the central nervous system can be

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. However, interpreting results is

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

Lymphocytic Choriomeningitis (LCM) Virus Ab, IFA (CSF)

Reference Range:  IgG  <1:1

                                    IgM  <1:1

 

Interpretive Criteria:

                 <1:1  Antibody Not Detected

        > or = 1:1  Antibody Detected

 

Diagnosis of infections of the central nervous system can be

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. However, interpreting results is

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps.

 

This assay was developed and its performance

characteristics determined by Focus Diagnostics. It has

not been cleared or approved by the U.S. Food and Drug

Administration. The FDA has determined that such

clearance or approval is not necessary.  Performance

characteristics refer to the analytical performance of the

test.

 

Herpes Simplex Virus 1/2 (IgG) Type-Specific Antibodies, CSF

Reference Range:  < or = 1.00

 

Interpretive Criteria:

                    < or = 1.00  Antibody Not Detected

                         >1.00      Antibody Detected

 

Detection of HSV type-specific IgG in CSF may indicate central

nervous system (CNS) infection by that HSV type.  However,

interpretation of results may be complicated by a number of

factors, including low antibody levels found in CSF, passive transfer

of antibody across the blood-brain barrier, and serum contamination

of CSF during CSF collection.  PCR detection of type-specific HSV

DNA in CSF is the preferred method for identifying HSV CNS infections.  

 

Herpes Simplex Virus (HSV) 1/2 IgM Antibody, IFA (CSF)

Reference Range:  <1:1

 

Interpretive Criteria

                     <1:1  Antibody Not Detected

            > or = 1:1  Antibody Detected

 

The IFA procedure for measuring IgM antibodies to HSV 1 and

 HSV 2 detects both type-common and type-specific HSV

antibodies.  Thus, elevated titers to both HSV 1 and HSV 2 may

represent crossreactive HSV antibodies rather than exposure to

both HSV 1 and HSV 2.

 

The intrathecal synthesis of HSV antibody is most accurately

measured by performing the Antibody Index for CNS Infection.

 

Diagnosis of central nervous system infections can be

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. Interpreting results may be

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via

bloody taps. The interpretation of CSF results must consider CSF-

serum antibody ratios to the infectious agent.

 

This assay was developed and its performance characteristics have

been determined by Focus Diagnostics. It has not been cleared or

approved by the U.S. Food and Drug Administration. The FDA has

determined that such clearance or approval is not necessary.

Performance characteristics refer to the analytical performance of the test.

 

Adenovirus Antibody, CF (CSF)

REFERENCE RANGE:  <1:1

 

INTERPRETIVE CRITERIA:

                  <1:1  Antibody Not Detected

            > or = 1:1  Antibody Detected

 

Diagnosis of infections of the central nervous system is

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. Interpretation of results may be

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody taps.

The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

This test was developed and its performance characteristics have

been determined by Focus Diagnostics. Performance characteristics

refer to the analytical performance of the test.

 

Influenza Type A and B Antibodies, CSF

REFERENCE RANGE:  <1:1

 

INTERPRETIVE CRITERIA:

                  <1:1  Antibody Not Detected

            > or = 1:1  Antibody Detected

 

Diagnosis of infections of the central nervous system is

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. Interpretation of results may be

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

This test was developed and its performance characteristics have

been determined by Focus Diagnostics. Performance characteristics

refer to the analytical performance of the test.

 

Measles (Rubeola) IgG and IgM Antibody Panel, IFA (CSF)

Reference Range:  IgG  <1:64

                                     IgM  <1:1

 

Diagnosis of central nervous system infections can be

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. Interpreting results may be

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

This assay was developed and its performance characteristics

have been determined by Focus Diagnostics. It has not been

cleared or approved by the U.S. Food and Drug Administration.

The FDA has determined that such clearance or approval is

not necessary. Performance characteristics refer to the analytical

performance of the test.

 

Mumps Antibody Panel, IFA (CSF)

Reference Range:   IgG  <1:8

                                     IgM  <1:1

 

Diagnosis of infections of the central nervous system is

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. Interpretation of results may be

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

This assay was developed and its performance characteristics

have been determined by Focus Diagnostics. It has not been

cleared or approved by the U.S. Food and Drug Administration.

The FDA has determined that such clearance or approval is

not necessary. Performance characteristics refer to the analytical

performance of the test.

 

Varicella-Zoster Virus Antibody, CSF

Reference Range:  <1:1

 

Interpretive Criteria:

                      <1:1  Antibody Not Detected

            > or = 1:1  Antibody Detected

 

Diagnosis of infections of the central nervous system is  

accomplished by demonstrating the presence of intrathecally-

 produced specific antibody. Interpretation of results may be

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

This test was developed and its performance characteristics have been

determined by Focus Diagnostics. Performance characteristics refer to

 the analytical performance of the test.

 

Coxsackie A Antibodies, CSF

Reference Range:  <1:1

 

Interpretive Criteria:

                     <1:1  Antibody Not Detected

            > or = 1:1  Antibody Detected

 

Diagnosis of infections of the central nervous system is

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. Interpretation of results may be

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps.The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

This test was developed and its performance characteristics have been

determined by Focus Diagnostics. Performance characteristics refer to

 the analytical performance of the test.

 

Coxsackie B (1-6) Antibodies, CSF

Reference Range:  <1:1

 

Interpretive Criteria:

                     <1:1  Antibody Not Detected

            > or = 1:1  Antibody Detected

 

Diagnosis of infections of the central nervous system is  

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. Interpretation of results may be

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

This test was developed and its performance characteristics have been

determined by Focus Diagnostics. Performance characteristics refer to

 the analytical performance of the test.

 

Echovirus Antibodies, CSF

Reference Range:  <1:1

 

Interpretive Criteria:

                     <1:1  Antibody Not Detected

            > or = 1:1  Antibody Detected

 

Diagnosis of infections of the central nervous system is  

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. Interpretation of results may be

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent.

 

Cytomegalovirus (CMV) IgG Antibody, ELISA (CSF)

Reference Range:  <0.80

 

Interpretive Criteria:

                     <0.80   Antibody not detected

            0.80 – 0.99   Equivocal

            > or = 1.00   Antibody detected

 

Diagnosis of infections of the central nervous system is

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. Interpretation of results may be

complicated by low antibody levels found in CSF, passive transfer

passive transfer of antibody from blood, and contamination via

bloody taps. The interpretation of CSF results must consider CSF-

serum antibody ratios to the infectious agent. The intrathecal

synthesis of CMV antibody is most accurately measured by

performing the Antibody Index for CNS Infection.

 

Cytomegalovirus (CMV) IgM Antibody, ELISA (CSF)

Reference Range:  <0.90

 

Interpretive Criteria:

                     <0.90   Antibody not detected

            0.90 - 1.09   Equivocal

            > or = 1.10   Antibody detected

 

Diagnosis of infections of the central nervous system is

accomplished by demonstrating the presence of intrathecally-

produced specific antibody. Interpretation of results may be

complicated by low antibody levels found in CSF, passive

transfer of antibody from blood, and contamination via bloody

taps. The interpretation of CSF results must consider CSF-serum

antibody ratios to the infectious agent. The intrathecal synthesis

of CMV antibody is most accurately measured by performing the

Antibody Index for CNS Infection.

 

West Nile Virus Antibody Panel, ELISA (CSF)

Reference Range:

IgG <1.30

IgM <0.90

 

Interpretive Criteria:

IgG:

 <1.30  Antibody not detected

 1.30 - 1.50  Equivocal

 >1.50  Antibody detected

 

IgM:  

<0.90  Antibody not detected

0.90 - 1.10  Equivocal

>1.10  Antibody detected

 

In the very early stages of acute West Nile Virus (WNV) infection, IgM

may be detectable in CSF before it becomes detectable in serum.  Antibodies

induced by other flavivirus infections (e.g., Dengue, St. Louis Encephalitis)

may show crossreactivity with WNV; thus, antibody detection using this panel

is not diagnostically conclusive for WNV infection. Final diagnosis should be

based on confirmatory assays, such as the plaque reduction neutralization test.

 

WNV antibody results for CSF should be interpreted with caution. Complicating

factors include low antibody levels found in CSF, passive transfer of antibody

from blood, and contamination via bloody taps.

 

Test Performed by: Focus Diagnostics, Inc.

                                      5785 Corporate Ave.

                                      Cypress, CA 90630