Lyme Disease Antibody Index for CNS Infection
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Lyme Disease Antibody Index:
< or = 1.0 Negative
1.1 - 1.2 Equivocal
> or = 1.3 Positive
Control Antibody Index: < or = 1.0
Albumin Ratio: <0.0078
The Lyme Disease Antibody Index is used as an aid for the diagnosis of neuroborreliosis. An increased Lyme Disease Antibody Index (>1.2), accompanied by a Control Antibody Index of less than 1.0 and an Albumin Ratio of less than 0.0078, is strong evidence for intrathecal synthesis of organism-specific antibody, and thus CNS B. burgdorferi infection. Elevation of either the control antibody index, the Albumin Ratio, or both may indicate leakage of antibody across the blood-brain barrier which may falsely elevate the Lyme Disease Antibody Index.