Mobile Site ›
Print Friendly View

Test ID: F_11    
Coagulation Factor XI Activity Assay, Plasma

Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosing deficiency of coagulation factor XI

 

Investigation of prolonged activated partial thromboplastin time

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Factor XI is synthesized in the liver. Its biological half-life is 60 to 80 hours. Factor XI is a component of intrinsic coagulation pathway which, when activated, activates factor IX to IXa.

 

Factor XI deficiency may cause prolonged partial thromboplastin time. Deficiency associated with mild bleeding diathesis, but there is poor correlation between activity level and clinical bleeding. A relatively high incidence of congenital deficiency occurs among Ashkenazi Jewish descent (hemophilia C).

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Adults: 55-150%

Normal, full-term newborn infants or healthy premature infants may have decreased levels (> or =10%) which may not reach adult levels for > or =180 days postnatal.*

*See Pediatric Hemostasis References in Coagulation Studies in Special Instructions.

Interpretation Provides information to assist in interpretation of the test results

Acquired deficiency is associated with liver disease and rarely inhibitors.

 

Homozygotes: <20%

 

Heterozygotes: 20% to 60%

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Decreased plasma levels of factor XI do not correlate well with bleeding risk.

Clinical Reference Provides recommendations for further in-depth reading of a clinical nature

1. He R, Chen D, He S: Factor XI: hemostasis, thrombosis, and antithrombosis. Thromb Res 2012 May;129(5):541-550

2. Martin-Salces M, Jimenez-Yuste V, Alvarez MT, et al: Review: Factor XI deficiency: review and management in pregnant women. Clin Appl Thromb Hemost 2010;16 (2):209-213

3. Seligsohn U. Factor XI in haemostasis and thrombosis: past, present and future. Thromb Haemost 2007;98(1):84-89

4. Santoro R, Prejano S, Iannaccaro P. Factor XI deficiency: a description of 34 cases and literature review. Blood Coagul Fibrinolysis 2011Jul;22(5):431-435

Special Instructions and Forms Describes specimen collection and preparation information, test algorithms, and other information pertinent to test. Also includes pertinent information and consent forms to be used when requesting a particular test