FHAN - Clinical: Hantavirus Antibodies (IgG, IgM) with Reflex to Confirmation

Test Catalog

Test ID: FHAN    
Hantavirus Antibodies (IgG, IgM) with Reflex to Confirmation  

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If Hantavirus IgG is >=2.00 and Hantavirus IgM is >=2.00 (FSING) Sin Nombre Virus IgG Confirmation will be performed at an additional charge.


If Hantavirus IgM is >=2.00 (FSINM) Sin Nombre Virus IgM Confirmation will be performed at an additional charge.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Reference Range:          <2.00


Interpretive Criteria:

                                    <2.00                Antibody not detected

> or = 2.00        Antibody detected


Two major groups of hantaviruses are recognized based on clinical presentation. The first group includes Sin Nombre Virus (SNV), which causes hantavirus pulmonary syndrome, a severe and sometimes fatal form of acute respiratory distress. A second group of hantaviruses (including Seoul, Hantaan, Dobrava, and Puumala) causes hemorrhagic fever with renal syndrome, a condition not typically seen in the United States.


Sera are initially screened for IgG and IgM antibodies recognizing the nucleocapsid protein common to all hantaviruses. All screen IgM positive samples are then tested for SNV-specific IgM; any screen IgM positive samples that are also screen IgG positive are tested for SNV-specific IgG, as well as SNV-specific IgM. Samples that are screen IgG positive but screen IgM negative are not subjected to SNV-specific IgG testing, since the lack of IgM rules out acute SNV infection.


A positive screening result but a negative SNV-specific antibody result may indicate either reactivity to a hantavirus other than SNV or false positive reactivity. A small number of SNV IgM positive (but screen IgG negative) samples represent false positive reactivity associated with acute cytomegalovirus or Epstein Barr virus infection.