Gonadotropin Releasing Hormone (Gn-RH)
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Gonadotropin-Releasing Hormone (Gn-RH), also known as
Luteinizing Hormone-Releasing Hormone (LH-RH), is a decapeptide
secreted pulsatily from the hypothalamus. It stimulates the release of
the Gonadotropins - Luteinizing Hormone and Follicle Stimulating
Hormone - exerting a stronger effect on Luteinizing Hormone.
Testosterone and Estradiol, whose release is stimulated by the
Gonadotropins, exert a negative feedback control on LH-RH both at
the hypothalamic site and by decreasing pituitary receptor binding.
LH-RH levels are low in patients with hypothalamic hypogonadism
differentiating them from the high levels usually found in primary
hypopituitary hypogonadism. Accentuation of the LH-RH pulse
occurs at the onset of puberty triggering the release of LH and FSH
required in pubertal development. LH-RH is stimulated by Epinephrine
and suppressed by Dopamine and opiates. LH-RH and some of its
agonists are frequently used to induce ovulation.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Adult Reference Range(s):
Males: 4.0-8.0 pg/mL
Females: 2.0-10.0 pg/mL
Test Performed by: Inter Science Institute
944 West Hype Park
Inglewood, CA 90302