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Unit Code 90158:
Elastase, Pancreatic, Serum

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Clinical Information

Elatase, also called Pancreatopeptidase, is a protease present in

pancreatic secretion with the unique ability to rapidly hydrolyze elastin.

Elastin is a fibrillar protein found in connective tissue. Elastin forms the

elastic fibers found mostly in lungs and skin. Elastase is able to hydrolyze

denatured hemoglobin, casein, fibrin, albumin and denatured but not

native collagen. Elastase has been implicated in the pathogenesis of

pulmonary emphysema, atherosclerosis and in the vascular injury of

acute pancreatic necrosis. Elastase activity is inhibited by protease

inhibitors including a1-Antitrypsin, A1-anti-chymotrypsin, antithrombin

III, a2-macroglobulin and b1-anti-Collagenase. Patients with thyroid

dysfunction have decreased Elatase activity.

Reference Values

Adult Reference Ranges:

Normal pancreatic exocrine function:

  Less than 3.5 ng/mL

 

No pediatric reference ranges available for this test.

 

This test was developed and its performance characteristics

determined by Inter Science Institute. It has not been cleared or

approved by the US Food and Drug Administration. The FDA

has determined that such clearance or approval is not necessary.

 

TEST PERFORMED BY

INTERSCIENCE INSTITUTE

944 WEST HYDE PARK

INGLEWOOD, CA  90302

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