|Values are valid only on day of printing.|
Demonstrating in vivo coating of RBCs with IgG or the complement component C3d in the following settings:
-Autoimmune hemolytic anemia
-Hemolytic transfusion reactions
-Drug-induced hemolytic anemia
IgG antibody or complement components secondary to the action of IgM antibody may be present on the patient's own RBCs or on transfused RBCs.
If positive, reaction is graded (micro positive to 4+).
Negative: no IgG antibody or complement (C3d) detected on the surface of the red cell.
Positive: IgG or complement (C3d) is present on the surface of the red cell.
Autoimmune hemolytic anemia can occasionally occur with a negative direct Coombs test.
The direct Coombs test can be positive in some apparently healthy individuals.
Technical Manual. Edited by: MK Fung, BJ Grossman, C Hillyer, CM Westhoff. AABB. 2014