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Test ID: FSULF    
Sulfatide Autoantibody Test

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Background information: Peripheral neuropathies (PNs) are a group of neurological disorders affecting one or more of the peripheral nerves (1,2). Causes of PN include nerve compression, genetic mutations, inflammation, metabolic abnormalities, vitamin deficiencies, exposure to toxins or drugs, or the presence of autoimmune antibodies (1). Symptoms of PN vary based on location and mechanism of nerve damage but can include sensory impairment, distal weakness, loss of sensation, muscle weakness, and pain (1,2). PNs are typically classified based on the types of nerves affected, predominantly motor, predominantly sensory, or a combination of both (2).

IgG and more commonly IgM Antibodies to sulfatide have been associated with sensory and sensory-motor neuropathies sometimes accompanied by pain (3,4,5). Additionally, IgG anti-sulfatide antibodies have been associated with distal sensory polyneuropathy (DSP) in individuals with HIV (6).

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Interpretive Criteria

Interpretation and Comments provided on each report.

Interpretation and Comments vary.  They are dependent upon

results.

 

Reference Range:

 

anti-Sulfatide IgG: Negative <1:2000

                     Borderline*

                     Positive >= 1:2000

 

anti-Sulfatide IgM: Negative <1:2000

                      Borderline*

                      Positive >= 1:2000

 

*Samples in the borderline range have an elevated level of anti-sulfatide antibodies on the screen assay, but the level of antibodies is below the positive cut off value.

 

Test Performed by: Athena Diagnostics

                             200 Forest Street, 2nd floor

                             Marlborough, MA 01752

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Limitations of analysis: Although rare, false positive or false negative results may occur. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data.

Clinical Reference Provides recommendations for further in-depth reading of a clinical nature

1. 1.  Andreoli et al. (2007) Cecil Essentials of Medicine. 7th ed. Sauders Elsevier. (ISBN-13: 978-1-4160-2933-5)

2.  2. Latov, N. (2007) Peripheral Neuropathy: When the Numbness, Weakness and Pain Won't Stop. AAN press. (ISBN-13: 978-1-932603-59-0)

3.  3.  Pestronk, A, et al. (1991) Neurology 41: 357-62, (PMID: 1706491)

4.  4. Lopate, G, et al. (1997) J Neurol Neurosurg Psychiatry 62: 581-5. (PMID: 9219742)

5.  5. van den Berg, LH, et al. (1993) J Neurol Neurosurg Psychiatry 56: 1164-8. (PMID: 8229027)

6.  6. Lopate, G, et al. (2005) Neurology 64: 1632-4. (PMID: 15883332)