Antibody Titer, Erythrocytes
Monitoring antibody levels during pregnancy to help assess the risk of hemolytic disease of the newborn
Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.
The initial test performed is an antibody identification. If the antibody problem identified is not relevant in hemolytic disease of the newborn, or if titrations are not helpful, the titer will be cancelled and will be replaced by the antibody identification test. Depending upon the antibody identification results, additional tests, ie, monospecific direct Coombs, antibody elution, antibody absorption, and red cell antigen typing may be added and charged. A consultation service is offered, at no charge, regarding the clinical relevance of red cell antibodies.
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Some maternal IgG alloantibodies to red blood cell antigens will cross the placenta and cause hemolysis of antigen-positive fetal red cells. The resulting fetal anemia and hyperbilirubinemia can be harmful or even fatal to the fetus or the newborn.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
If positive, result will be reported as the reciprocal of the highest dilution at which macroscopic agglutination (1+) is observed.
The specificity of the maternal alloantibody will be stated. The titer result is the reciprocal of the highest dilution at which macroscopic agglutination (1+) is observed.
If the antibody problem identified is not relevant in hemolytic disease of the newborn or if titrations are not helpful, the titer will be canceled and will be replaced by ABID2 / Antibody Identification, Erythrocytes.
A consultation service is offered, at no charge, regarding the clinical relevance of red cell antibodies.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Not useful for evaluating the efficacy of Rh-immune globulin after it has been administered
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
Technical Manual. Bethesda, MD, American Association of Blood Banks