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Detection of cold agglutinins in patients with suspected cold agglutinin disease
The cold agglutinin titer test is to be used as a tool in the evaluation of suspected cold agglutinin syndrome. In this syndrome, cold agglutinins, usually IgM with anti-I specificity, attach to the patient's erythrocytes causing a variety of symptoms, from chronic anemia due to premature removal of the sensitized erythrocytes from circulation by hemolysis to acrocyanosis of the ears, fingers, or toes due to local blood stasis in the skin capillaries.
-Negative (no cold agglutinin detected)
-Positive (cold agglutinin detected, titer end point range will be reported)
-Patients with cold agglutinin syndrome usually exhibit a titer value >1:512, with rare cases reportedly as low as 1:64.
-Normal individuals often have low levels of cold agglutinins.
The test is not a direct measure of clinical significance and must be used in conjunction with other in vitro and in vivo parameters.
Normal individuals may have low levels of cold agglutinins. The cold agglutinins test is not specific for Mycoplasma pneumoniae and is not recommended to diagnose Mycoplasma pneumoniae infections. See MYCPN / Mycoplasma pneumoniae Antibodies, IgG and IgM, Serum.
1. Petz LD, Garratty G: Acquired Immune Hemolytic Anemias. New York, Churchill Livingstone, 1980
2. Farratty G, Petz LD, Hoops JK: The correlation of cold agglutinin titrations in saline and albumin with haemolytic anaemia. Br J Haematol 1977;35:587-595