|Values are valid only on day of printing.|
Assessing positive pretransfusion antibody screens, transfusion reactions, hemolytic disease of the newborn, and autoimmune hemolytic anemias
The following tests may also be ordered and performed as part of antibody identification: special red cell antigen typing, antibody elution, antibody absorption, direct Coombs, and monospecific direct Coombs. These additional tests will determine or confirm antibody specificity and allo- vs. autoantibody.
After exposure to foreign red blood cells via transfusion or pregnancy, some people form antibodies which are capable of the destruction of transfused red cells or of fetal red cells in utero. It is important to identify the antibody specificity in order to assess the antibody's capability of causing clinical harm and, if necessary, to avoid the antigen on transfused red blood cells.
If positive, antibodies will be identified and corresponding special red cell antigen typing on patient's red blood cells will be performed. A consultation service is offered, at no charge, regarding the clinical relevance of red cell antibodies.
Specificity of alloantibodies will be stated.
The patient's red blood cells will be typed for absence of the corresponding antigen(s) or as an aid to identification in complex cases.
A consultation service is offered, at no charge, regarding the clinical relevance of red cell antibodies.
Recent administration of Rh-immune globulin may cause anti-D to be identified and appear falsely as an alloantibody
Not useful for monitoring the efficacy of Rh-immune globulin administration
Not useful for identifying antibodies detected only at 4 degrees C or only after extended room temperature incubation
Technical Manual. Bethesda, MD, American Association of Blood Banks