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Unit Code 89040:
T-Cell Lymphoma, FISH, Blood or Bone Marrow

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Useful For

Detecting a neoplastic clone associated with the common chromosome

anomalies seen in patients with various T-cell lymphomas 

 

Tracking known chromosome anomalies and response to therapy in

patients with T-cell lymphoma

Clinical Information

T-cell neoplasms are relatively uncommon, accounting for approximately

12% of all non-Hodgkin lymphomas. There are several subtypes of

T-cell neoplasms:  T-cell acute lymphoblastic leukemia (T-ALL), T-cell

prolymphocytic leukemia (T-PLL), T-cell large granular lymphocytic

leukemia (T-LGL), anaplastic large cell lymphoma (ALCL), peripheral

T-cell lymphoma, and various other cutaneous, nodal, and extranodal

lymphoma subtypes. The 2 most prevalent lymphoma subtypes are

unspecified peripheral T-cell lymphoma (3.7%) and ALCL (2.4%). T-cell

neoplasms are among the most aggressive of all hematologic and

lymphoid neoplasms with the exception of ALCL, which is usually

responsive to chemotherapy.  

 

There are a few common chromosome anomalies associated with

specific subtypes, which this FISH test can detect:

 - inv(14)(q11q32) and t(14;14)(q11;q32), which involve the T-cell
   leukemia/lymphoma 1 gene (TCL1) and have been associated
   with T-PLL

 - Isochromosome 7q and trisomy 8, which have been associated
   with hepatosplenic T-cell lymphoma

 

These probes have diagnostic relevance and can also be used to track

response to therapy.

 

This assay detects chromosome abnormalities observed in the blood and

bone marrow of patients with T-cell lymphoma (for patients with T-cell

acute leukemia, see #88783 "T-Cell Acute Lymphoblastic Leukemia

[T-ALL], FISH").

Reference Values

An interpretive report is provided.

Interpretation

A neoplastic clone is detected when the percent of cells with an

abnormality exceeds the normal reference range for any given probe.

 

Detection of an abnormal clone supports a diagnosis of a T-cell

lymphoma. The specific anomaly detected may help subtype the

neoplasm.

 

The absence of an abnormal clone does not rule out the presence of

neoplastic disorder.

Cautions

This test should not be ordered on patients with T-ALL. In these situations,

see #88783 "T-Cell Acute Lymphoblastic Leukemia (ALL), FISH."

 

This test is not Food and Drug Administration (FDA)-approved; and it is

best used as an adjunct to existing clinical and pathologic information.

Special Instructions and Forms

• Cytogenetics Hematologic FISH Panel Patient Information 

Clinical Reference

1.   World Heath Organization Classification of Tumours. Pathology and

       Genetics of Tumours of Haematopoietic and Lymphoid Tissues.

       Edited by ES Jaffe, NL Harris, H Stein, JW Vardiman. Lyon, IARC

       Press, 2001

2.   Gesk S, Martin-Subero JI, Harder L, et al:  Molecular cytogenetic

       detection of chromosomal breakpoints in T-cell receptor gene loci.

       Leukemia 2003;17:738-745

3.   Chin M, Mugishima H, Takamura M, et al:  Hemophagocytic syndrome

      and hepatosplenic (gamma)(delta) T-cell lymphoma with

      isochromosome 7q and 8 trisomy. J Pediatr Hematol Oncol 2004;

      26(6):375-378

Key