Pigeon Breeders Disease Serology, Serum
Evaluation of patients suspected of having hypersensitivity pneumonitis induced by exposure to pigeon droppings
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Avian proteins, including antigens in pigeon droppings, are one of the causative agents of hypersensitivity pneumonitis (HP). The development of HP caused by avian proteins is accompanied by an immune response to avian protein antigens with production of IgG antibodies. While the immunopathogenesis of HP is not known, several immune mechanisms are postulated to play a role, including both cellular and humoral mechanisms.(1)
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
> or =16 years: < or =53.3 mg/L
Elevated concentrations of IgG antibodies to pigeon droppings in patients with signs and symptoms of hypersensitivity pneumonitis may be consistent with disease caused by exposure to this antigen.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
IgG antibodies to pigeon droppings may be found in sera from healthy individuals; the presence of these specific antibodies is not sufficient to establish the diagnosis of hypersensitivity pneumonitis (HP).
The concentrations of antibodies to these antigens may decrease following treatment, although elevated concentrations may persist in treated patients.
Clinical Reference Provides recommendations for further in-depth reading of a clinical nature
1. Fink JN, Zacharisen MC: Chapter 69: Hypersensitivity pneumonitis. In Allergy Principles and Practice. Vol 1. Fifth edition. Edited by E Middleton Jr, CE Reed, EF Ellis, et al. St. Louis, MO, Mosby Year Book, Inc., 1998
2. Girard M, Lacasse Y, Cormier Y: Hypersensitivity pneumonitis. Allergy 2009;64:322-334
3. Grunes D, Beasley MB: Hypersensitivity pneumonitis: A review and update of histologic findings. J Clin Pathol 2013;66:888-895