|Values are valid only on day of printing.|
The differential diagnosis of hypercalcemia
An adjunct to serum parathyroid hormone measurements, especially in the diagnosis of parathyroid hormone resistance states, such as pseudohypoparathyroidism
Cyclic AMP functions as an intracellular "second messenger" regulating the activity of intracellular enzymes or proteins in response to a variety of hormones (eg, parathyroid hormone).
Urinary cyclic AMP is elevated in about 85% of patients with hyperparathyroidism.
1.3-3.7 nmol/dL of glomerular filtrate
Urinary cyclic AMP is elevated in about 85% of patients with hyperparathyroidism and in about 50% of patients with humoral hypercalcemia of malignancy.
Parathyroid suppression (hypoparathyroidism) does not lower urinary cyclic AMP excretion to definitely subnormal values.
Aurbach GD, Marx SJ, Spiegel AM: Parathyroid hormone, calcitonin, and the calciferols. In Williams Textbook of Endocrinology. Eighth edition. Edited by JD Wilson, DW Foster. Philadelphia, WB Saunders Company, 1992, pp 1413-1415