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Test ID: GRP    
Cyclic AMP, Urinary Excretion

Useful For Suggests clinical disorders or settings where the test may be helpful

The differential diagnosis of hypercalcemia

 

An adjunct to serum parathyroid hormone measurements, especially in the diagnosis of parathyroid hormone resistance states, such as pseudohypoparathyroidism

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Cyclic AMP functions as an intracellular "second messenger" regulating the activity of intracellular enzymes or proteins in response to a variety of hormones (eg, parathyroid hormone).

 

Urinary cyclic AMP is elevated in about 85% of patients with hyperparathyroidism.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

1.3-3.7 nmol/dL of glomerular filtrate      

Interpretation Provides information to assist in interpretation of the test results

Urinary cyclic AMP is elevated in about 85% of patients with hyperparathyroidism and in about 50% of patients with humoral hypercalcemia of malignancy.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Parathyroid suppression (hypoparathyroidism) does not lower urinary cyclic AMP excretion to definitely subnormal values.

Clinical Reference Provides recommendations for further in-depth reading of a clinical nature

Aurbach GD, Marx SJ, Spiegel AM: Parathyroid hormone, calcitonin, and the calciferols. In Williams Textbook of Endocrinology. Eighth edition. Edited by JD Wilson, DW Foster. Philadelphia, WB Saunders Company, 1992, pp 1413-1415