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Test ID: P_PB    
Phenytoin, Total and Phenobarbital Group, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

See individual test descriptions for:

-PNY/8604 Phenytoin, Total, Serum

-PBAR/8252 Phenobarbital, Serum

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

See individual test descriptions for:

-PNY/8604 Phenytoin, Total, Serum

-PBAR/8252 Phenobarbital, Serum

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

PHENYTOIN, TOTAL

Therapeutic concentration: 10.0-20.0 mcg/mL

Toxic concentration: > or =30.0 mcg/mL

 

PHENOBARBITAL

Therapeutic concentration

Infants and children: 15.0-30.0 mcg/mL

Adults: 20.0-40.0 mcg/mL

Toxic concentration: > or =60.0 mcg/mL

Interpretation Provides information to assist in interpretation of the test results

See individual test descriptions for:

-PNY/8604 Phenytoin, Total, Serum

-PBAR/8252 Phenobarbital, Serum

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

See individual test descriptions for:

-PNY/8604 Phenytoin, Total, Serum

-PBAR/8252 Phenobarbital, Serum

Supportive Data

See individual test descriptions for:

-PNY/8604 Phenytoin, Total, Serum

-PBAR/8252 Phenobarbital, Serum

Clinical Reference Provides recommendations for further in-depth reading of a clinical nature

Phenytoin, Total:

1. Richens A: Clinical pharmacokinetics of phenytoin. Clin Pharmacokinet 1979;4:153-169

2. Moyer TP: Therapeutic drug monitoring. In Tietz Textbook of Clinical Chemistry. Fourth edition. Edited by CA Burtis, ER Ashwood. WB Saunders Company, Philadelphia, 2005, pp 1237-1285

 

Phenobarbital:

Foero O, Kastrup KW, Nielsen EL, et al: Successful prophylaxis of febrile convulsions with phenobarbital. Epilepsia 1972;13:279-285