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Monitoring butalbital therapy
Butalbital is a short-acting barbiturate with hypnotic properties that is used in combination with other drugs such as acetaminophen, salicylate, caffeine, and codeine.(1)
Butalbital is administered orally. The duration of its hypnotic effect is about 3 to 4 hours. The drug distributes throughout the body, with a volume of distribution (Vd) of 0.8 L/kg, and about 26% of a dose is bound to plasma proteins. Butalbital's half-life is about 35 to 88 hours. Excretion occurs mainly in the urine.(1,2)
Butalbital level > or =10 mcg/mL is toxic
No significant cautionary statements.
1. Disposition of Toxic Drugs and Chemicals in Man. Seventh edition. Edited by RC Baselt. Foster City, CA, Biomedical Publications, 2004, p 1254
2. Teitz Textbook of Clinical Chemistry and Molecular Diagnostics. Fourth edition. Edited by CA Burtis, ER Ashwood, DE Bruns. St. Louis, MO, Elsevier