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Aiding in the diagnosis of central nervous system infection by mumps virus
There is only 1 serotype of mumps virus that infects humans. Mumps has been recognized since antiquity by virtue of the parotitis that is often a striking clinical feature of the disease. Generally, a trivial childhood illness, the varied presentation of mumps reflects the widespread invasion of visceral organs and central nervous system that commonly follows infection with mumps virus.
Detection of organism-specific antibodies in the cerebrospinal fluid (CSF) may suggest central nervous system infection. However, these results are unable to distinguish between intrathecal antibodies and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. The results should be interpreted with other laboratory and clinical data prior to a diagnosis of central nervous system infection.
No significant cautionary statements.
Wolinsky J, Waxham MN: Mumps virus. In Fields Virology. Vol 1. Second edition. Edited by BN Fields, DM Knipe. New York, Raven Press, 1990, pp 989-1011