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Detection of Epstein-Barr virus encoded RNA (EBER) in the diagnosis of EBV-associated conditions
Epstein-Barr virus (EBV) plays a pathogenic role in a variety of disease states, including infectious mononucleosis, nasopharyngeal carcinoma, Burkitt lymphoma, B-cell lymphomas in patients with congenital or acquired immunodeficiency, and some cases of classical Hodgkin lymphoma.
This test, when not accompanied by a pathology consultation request, will be answered as either positive or negative. If additional interpretation/analysis is needed, please request test 70012 / Pathology Consultation along with this test.
No significant cautionary statements.
1. Wu TC, Mann RB, Epstein JI, et al: Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma. A morphologically distinctive target for detection of Epstein-Barr virus in formalin-fixed paraffin-embedded carcinoma specimens. Am J Pathol 1991;138:1461-1469
2. Randhawa PS, Jaffe R, Demetris AJ, et al: The systemic distribution of Epstein-Barr virus genomes in fatal post-transplantation lymphoproliferative disorders. An in situ hybridization study. Am J Pathol 1991;138:1027-1033
3. Chang KL, Chen YY, Shibata D, Weiss LM: Description of an in situ hybridization methodology for detection of Epstein-Barr Virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues. Diagn Mol Pathol 1992;1:246-255