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Unit Code 80132:
Nafcillin

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Useful For

Monitoring nafcillin therapy, especially in patients in renal failure

 

Evaluating patient compliance

Clinical Information

Nafcillin is used for treatment of infections by gram-positive bacteria

such as Enterococcus faecalis, Staphylococcus species, Streptococcus

pneumonia, and B-hemolytic strains of streptococcus.

 

Nafcillin has a wide therapeutic index and dose-dependent toxicity.

Accordingly, routine drug monitoring is not indicated in all patients.

Nafcillin accumulates in renal failure patients.

Reference Values

PLASMA OR SERUM

      Peak:  1-9 ug/mL

      No trough therapeutic range established.

SPINAL FLUID

      No established reference values

Interpretation

The antibacterial effect will not be achieved if the blood concentration

is <3 ug/mL. No additional benefit is associated with blood

concentration >9 ug/mL.

Cautions

No significant cautionary statements

Clinical Reference

Mandell GL:  Principles and Practice of Infectious Diseases. Churchill

Livingston Press, London, 1995

Key