Unit Code 800079:
Uric Acid, Urine
Useful For
Assessment and management of patients with kidney
stones, particularly uric acid stones
Clinical Information
Uric acid is the end-product of purine metabolism. It is freely
filtered by the glomeruli and most is reabsorbed by the tubules.
There is also active tubular secretion.
Increased levels of uric acid in the urine usually accompany
increased plasma uric acid levels unless there is a decreased
excretion of uric acid by the kidneys. Urine uric acid levels reflect
the amount of dietary purines and also endogenous nucleic acid
breakdown.
Reference Values
Diet-dependent: <750 mg/specimen
The reference value is for a 24-hour collection. Specimens
collected for other than a 24-hour time period are reported
in unit of mg/dL for which reference values are not established.
Interpretation
Urinary uric acid excretion is elevated in a significant proportion
of patients with uric acid stones.
Uric acid excretion can be either decreased or increased in
response to a variety of pharmacologic agents.
Urine uric acid levels are elevated in states of uric acid overproduction
such as in leukemia and polycythemia and after intake of food rich
in nucleoproteins.
Cautions
High levels of bilirubin and ascorbic acid may interfere with
measurement.
Special Instructions and Forms
Clinical Reference
Newman DJ, Price CP: Renal function and nitrogen metabolites.
In Textbook of Clinical Chemistry. Edited by NW Tietz. Philadelphia,
WB Saunders Company, 1999, pp 1245-1250
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