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Test ID: HFH    
Hematologic Disorders, Fluorescence In Situ Hybridization (FISH) Hold, Bone Marrow or Peripheral Blood

Useful For Suggests clinical disorders or settings where the test may be helpful

Processing the bone marrow or peripheral blood specimen but delaying FISH analysis while preliminary morphologic assessment is in process

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Fluorescence in situ hybridization (FISH)  analysis using gene specific probes is a useful methodology to detect common, recurrent chromosome abnormalities for most hematologic malignancies. Based on morphologic review of the bone marrow or peripheral blood specimen by a hematopathologist, a determination of additional appropriate testing can be made. If the specimen does not show evidence of malignancy, FISH analysis may not be necessary. Depending on the diagnosis, conventional chromosome analysis may also be more informative.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Not applicable

Interpretation Provides information to assist in interpretation of the test results

If notified by the client, this test may be canceled and a processing fee will be assessed.


If no notification to cancel testing is received, this test will be reported as "reflexed for FISH analysis," and the FISH assay indicated with Heme FISH Hold test order will be performed and an interpretive report provided.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

This test does not apply to chromosome analysis. If chromosome analysis is to be held, then HCH / Hematologic Disorders, Chromosome Hold, Bone Marrow or Peripheral Blood must be ordered.


The Heme FISH Hold test does not apply to the Plasma Cell Proliferative Disorder (PCPD), FISH (FPCPD) assay.